scholarly journals Synthesis, Characterization and Antimicrobial Evaluation of Schiff’s Base and Aryl Aminomethyl Derivatives

2016 ◽  
Vol 64 ◽  
pp. 89-94
Author(s):  
N.N. Kansagara ◽  
V.R. Dangar ◽  
V.R. Shah
Keyword(s):  
Selective Reduction ◽  
Schiff’S Bases ◽  
Schiff’S Base ◽  
Chemical Structures ◽  
Imine Group ◽  
Schiff's Bases ◽  
Aminomethyl Derivatives ◽  
Aryl Amines ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal

Schiff’s bases are obtained on heating an aldehydes with aromatic amine in presence of glacial acetic acid. These are the compounds containing characteristic –HC=N– group. Aryl amino methyl derivatives of heterocyclic compounds to synthesize by selective reduction of schiff’s bases (imine group) with sodiumborohydride in controlled experimental condition. Schiff’s base of N-Aryl-1-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]methanimines & Aryl amines of N-Aryl-1-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]methanamines were prepared. Their chemical structures were confirmed by means of IR, NMR, Mass data and by elemental analysis. All of the synthesized compounds were tested for their antibacterial and antifungal activity.

MICROWAVE ASSISTED SYNTHESIS OF BIPHENYL BASED SCHIFF’S BASES AND THEIR ANTIMICROBIAL EVALUATION

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (03) ◽  
pp. 13-18
Author(s):  
R. Somani ◽  
◽  
P. Dubey ◽  
S. Zine
Keyword(s):  
Biological Activities ◽  
Biological Membrane ◽  
Log P ◽  
Microwave Assisted Synthesis ◽  
Schiff’S Bases ◽  
Schiff’S Base ◽  
Schiff's Bases ◽  
Phenyl Rings ◽  
Antimicrobial Evaluation ◽  
Anti Fungal

Schiff’s base constitutes a significant class of compounds for new drug development. They are widely used for industrial purposes and also exhibit a broad range of biological activities. The search for Schiff’s base containing compounds with more selective activity and lower side effects continues to be an active area of argument examination in medicinal chemistry. The biphenyl molecule consists of two connected phenyl rings. Biphenyl ring scaffolds are fairly non-reactive in nature. They enhance the log-P values; increase the tropical polar surface area (TPSA) of the molecule, act as hydrophobic carrier across biological membrane, thus, increasing the bioavailability of compounds. In the present work, a series of Schiff’s bases of biphenyl-4-carboxylic acid have been synthesized. These derivatives were characterized by elemental analysis, IR, and 1H NMR spectral data and have been explored for anti-bacterial, anti-fungal and anti-tubercular activities. The synthesized compounds have shown excellent anti-fungal potential, making them good candidates for future studies in antifungal research.

scholarly journals Synthesis of Schiff’s Bases from 2-Amino-4H-1, 3-Oxazine / Thiazine and Substituted Aldehydes and their Transition Metal Complexes

2021 ◽  
Vol 04 (07) ◽  
Author(s):  
D.T. Biradar ◽  
Keyword(s):  
Acetic Acid ◽  
Metal Complexes ◽  
Bioactive Molecules ◽  
Schiff’S Bases ◽  
Schiff’S Base ◽  
One Pot ◽  
Solvent Free Condition ◽  
Synthetic Strategy ◽  
Schiff's Bases

Objective: Many methods can be found in literature for the synthesis a Oxazines and Thiazines. Few are reported for one-pot multi component cyclo-condensation of an alkayane urea / Thiourea and Aldehyde to 2- amino-4H-1, 3-Oxazines or Thiazines. Different catalysts are reported like Trifluoro-acetic acid, glacial acetic acid under reflux condition Mandal and Co-workers have utilized perchloric acid (HClO4) supported on silica gel as catalyst under solvent free condition ytterbium trifluorate [Yb(OTF)3] plays role of Lewis acid. It is also used in several Diel’s-Alder cyclo-addition reactions. Inspired these observations, development of simple effective synthetic strategy for the synthesis of 2-amino-4H-1, 3-Oxazium & Thiazines was attempted. Material and Methods: One pot multi-component synthesis of Schiff’s base as new ligand an their complexes with Ni, Fe, Co and Cu and developed using 2-amino-4H-1,3 Oxazines /Thiazines and substituted Aldehydes, different catalyst are used to synthesize of 2-amino 4H-1,3 Oxazines. Its characterization is confirmed by taking IR, NMR spectra. The Schiff’s base act as ligand is bidentate, when it is treated to metal complexes in 1:1 ratio (metal: ligand) complexes are formed. Result: By using the bioactive molecules like 2-amino-4H-1, 3 Oxazine / Thiazines, Schiff’s Bases can be synthesized by using different aldehydes. These Schiff’s Bases has antitumor, antipyretic, anti-inflammatory property. And these Schiff’s bases treated with bioactive metals like Co, Fe, Cu, Zn which enhances their bio-activity. Conclusion: All these synthesized Schiff’ Bases and their metal complexes having bioactive properties.

scholarly journals SYNTHESIS OF A NOVEL SERIES OF SCHIFF’S BASES FROM PABA AND PHENYL HYDRAZINE AND EVALUATION OF THEIR ANTIOXIDANT ACTIVITY

2021 ◽  
pp. 271-273
Author(s):  
Yalamanchili Praharsha ◽  
Sashmitha Samuel.B
Keyword(s):  
Potential Role ◽  
Antibacterial Activities ◽  
Schiff’S Bases ◽  
Phenyl Hydrazine ◽  
Efficient Procedure ◽  
Schiff's Bases ◽  
Anti Oxidant ◽  
Antibacterial And Antifungal ◽  
Areas Of Interest ◽  
Therapeutic Activities

Over the past decade, the synthesis of Schiff’s bases has become one of the main areas of interest in synthetic chemistry. These compounds have gained much attention, owing to their potential role as anti-inflammatory, anthelmintic, analgesic, antibacterial and antifungal agents. Thus, in view of the significance and diverse therapeutic activities of Schiff’s bases we have aimed at a simple and efficient procedure for their synthesis by the reaction of various aldehydes with PABA and phenyl hydrazine and also evaluation of their antibacterial activities. We have been successful in synthesizing various Schiff’s bases and also these compounds have been proved to have effective anti-oxidant activity. KEYWORDS: Schiff’s bases, PABA, Phenyl hydrazine, Aldehydes, Dioxan, Hydrogen peroxide, scavenging activity

Synthesis and Biological Evaluation of Chalconyl Incorporated Schiff’s Bases of Sulphonamides

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Neeraj Kumar ◽  
Dhruti Bhatt ◽  
Chandra Shekhar Sharma ◽  
Hamendra Pratap Singh ◽  
Harshda Pandiya ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Biological Evaluation ◽  
Antibacterial And Antifungal Activity ◽  
Schiff’S Bases ◽  
E Coli ◽  
Schiff's Bases ◽  
Microbial Strains ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation

A series of of Chalconyl Incorporated Schiff’s Bases of Sulphonamides was synthesized by reacting substituted chalcone derivatives with Sulphacetamide sodium in methanol. All the title compounds synthesized (2a-2d) were tested for antibacterial and antifungal activity using E. coli, P. aeruginosa, S. aureus, S. pyogenus and C. albicans, A. niger and A. clavatus respectively as microbial strains and Sulphacetamide sodium as standard. The compound 2d showed significant antibacterial activity and 2a showed moderate antifungal activity as compared with Sulphacetamide Sodium.

scholarly journals The synthesis and antimicrobial study of some azetidinone derivatives with the para-anisidine moiety

2007 ◽  
Vol 72 (5) ◽  
pp. 437-442 ◽  
Author(s):  
Ishwar Bhat ◽  
Sunil Chaithanya ◽  
P.D. Satyanarayana ◽  
Balakrishna Kalluraya
Keyword(s):  
1H Nmr ◽  
Spectroscopic Analysis ◽  
Aromatic Aldehydes ◽  
Chloroacetyl Chloride ◽  
Schiff’S Bases ◽  
Antimicrobial Study ◽  
Schiff's Bases ◽  
Agar Disc ◽  
Antifungal Potential ◽  
Antibacterial And Antifungal

Azetidinones were synthesized from p-anisidine in two steps. First the Schiff's bases were prepared by reacting the hydrazide of an anisidine derivative with different aromatic aldehydes. Cyclocondensation of the Schiff's bases with chloroacetyl chloride in the presence of triethylamine resulted in the formation of the corresponding azetidinone analogues. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR and mass spectroscopic analysis. The antibacterial and antifungal potential of the synthesized compounds were evaluated by the agar disc method.

scholarly journals Perchloric acid catalyzed condensation of amine and aldehydes: Synthesis and antibacterial activities of some aryl (E)-imines

2014 ◽  
Vol 69 (1-2) ◽  
Author(s):  
P. Mayavel ◽  
K. Thirumurthy ◽  
S. Dineshkumar ◽  
G. Thirunarayanana
Keyword(s):  
Perchloric Acid ◽  
Antibacterial Activities ◽  
Schiff’S Bases ◽  
Physical Constants ◽  
Schiff's Bases ◽  
Aryl Amines ◽  
Acid Catalyzed ◽  
Substituted Benzaldehydes

AbstractA series of Schiff’s bases (aryl E-imines) have been derived from the perchloric acid catalyzed condensation of aryl amines and substituted benzaldehydes. The yield of the Schiff’s bases are more than 80%. The synthesized Schiff’s bases are characterized by their physical constants, analytical and spectroscopical data. The antibacterial activities of these Schiff’s bases have been studied using Bauer-Kirby method.

Green Synthesis, Characterization, DPPH and Ferrous Ion-chelating (FIC) Activity of Tetrakis-Schiff’s Bases of Terephthalaldehyde

2019 ◽  
Vol 16 (3) ◽  
pp. 249-255
Author(s):  
Momin Khan ◽  
Umar Ali ◽  
Anis Ur Rahman ◽  
Muhammad Ibrahim ◽  
Abdul Hameed ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Aromatic Aldehydes ◽  
Ferrous Ion ◽  
Future Research ◽  
Scavenging Activity ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Antioxidant Agents

Background: The role of small molecules as antioxidants to prevent the oxidation of other molecules and inhibit them from radical formation is the area of much interest to cure disease especially cancer. Moreover, the antioxidants play important role as stabilizers to prevent oxidation of fuels and lubricants. </P><P> Methods: In the present study, fifteen tetrakis-Schiff’s bases derivatives (1-15) were synthesized and screened for their antioxidant activities. Compounds 1-15 were synthesized by continuous stirring of reaction mixture of 1,4-bis (hydrazonomethyl)benzene (1 mmol) with various substituted aromatic aldehydes (2 mmol) in distilled water using acetic acid as catalyst at room temperature for 2-10 min. </P><P> Results: Our present study showed that all compounds are better ferrous ion-chelating agents except compound 1,4-bis((E)-((E)-(3,4-dimethoxybenzylidene)hydrazono)methyl)benzene (6) (IC50 = 329.26 &#177; 4.75 &#181;M) which has slightly low activity than the standard EDTA (IC50 = 318.40 &#177; 5.53 μM). In addition, DPPH radical scavenging activity of eleven compounds showed higher activity than the standard. However, remaining four compounds showed comparable radical scavenging activity to the standard DPPH (IC50 = 257.77 &#177; 4.60 &#181;M). </P><P> Conclusion: The series of fifteen Schiff’s bases (1-15) were synthesized and evaluated as antioxidants. From both assays, it has been demonstrated that most of the tetrakis-Schiff’s bases have potential to serve as leads for the development of antioxidant agents for future research.

Synthesis of Schiff's bases Derived from 2- Amino - 1,3,4- Thiadiazole and 1,3,4- Oxadiazole with Naphthaldehydes

2006 ◽  
Vol 9 (1) ◽  
pp. 21-28
Author(s):  
Emaad . T. bakir Al-Takrity ◽  
◽  
Ibtisam K. Jassim ◽  
Wissam K. Jassim ◽  
◽  
...  
Keyword(s):  
Schiff’S Bases ◽  
Schiff's Bases
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