Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves

2010 ◽  
Vol 55 (1) ◽  
pp. 43-52 ◽  
Author(s):  
JJ Luszczki
Keyword(s):  
Dose Response ◽  
Maximal Electroshock ◽  
Type I ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Isobolographic Analysis ◽  
Seizure Model

scholarly journals Additive interaction of levetiracetam with lamotrigine in the mouse 6 Hz psychomotor seizure model – an isobolographic analysis

2015 ◽  
Vol 26 (1) ◽  
pp. 82-87
Keyword(s):  
Dose Response ◽  
Seizure Activity ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Additive Interaction ◽  
Isobolographic Analysis ◽  
Psychomotor Seizure ◽  
Seizure Model ◽  
A Current ◽  
Anticonvulsant Effects

The aim of this study was to characterize the anticonvulsant effects of levetiracetam (LEV) in combination with lamotrigine (LTG – a second-generation antiepileptic drug), in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes and isobolographic analysis for parallel dose-response relationship curves (DRRCs) was used to characterize the consequent anticonvulsant interactions between the drug combinations. Results indicated that LEV administered singly was associated with a DRRC that was parallel to that for LTG. With isobolography for parallel DRRCs, the combination of LEV with LTG at three fixed-ratios of 1:3, 1:1 and 3:1 exerted additive interaction. LEV combined with LTG exerted additive interaction in the mouse 6 Hz psychomotor seizure model.

Beneficial Combination of Lacosamide with Retigabine in Experimental Animals: An Isobolographic Analysis

Pharmacology ◽  
2017 ◽  
Vol 101 (1-2) ◽  
pp. 22-28 ◽  
Author(s):  
Jarogniew J. Luszczki ◽  
Mirosław Zagaja ◽  
Barbara Miziak ◽  
Maria W. Kondrat-Wrobel ◽  
Katarzyna Zaluska ◽  
...  
Keyword(s):  
Dose Response ◽  
Treatment Plan ◽  
Linear Regression Analysis ◽  
Fixed Ratio ◽  
Maximal Electroshock ◽  
Type I ◽  
Additive Interaction ◽  
Pharmacoresistant Epilepsy ◽  
Isobolographic Analysis ◽  
Chimney Test

Background/Aim: To isobolographically determine the types of interactions that occur between retigabine and lacosamide (LCM; two third-generation antiepileptic drugs) with respect to their anticonvulsant activity and acute adverse effects (sedation) in the maximal electroshock-induced seizures (MES) and chimney test (motor performance) in adult male Swiss mice. Methods: Type I isobolographic analysis for nonparallel dose-response effects for the combination of retigabine with LCM (at the fixed-ratio of 1:1) in both the MES and chimney test in mice was performed. Brain concentrations of retigabine and LCM were measured by high-pressure liquid chromatography (HPLC) to characterize any pharmacokinetic interactions occurring when combining these drugs. Results: Linear regression analysis revealed that retigabine had its dose-response effect line nonparallel to that of LCM in both the MES and chimney tests. The type I isobolographic analysis illustrated that retigabine combined with LCM (fixed-ratio of 1:1) exerted an additive interaction in the mouse MES model and sub-additivity (antagonism) in the chimney test. With HPLC, retigabine and LCM did not mutually change their total brain concentrations, thereby confirming the pharmacodynamic nature of the interaction. Conclusion: LCM combined with retigabine possesses a beneficial preclinical profile (benefit index ranged from 2.07 to 2.50) and this 2-drug combination is worth recommending as treatment plan to patients with pharmacoresistant epilepsy.

A SUBCUTANEOUS INJECTION ASSAY FOR ANTI-ANDROGENS IN THE CHICK

1962 ◽  
Vol 41 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Ralph I. Dorfman
Keyword(s):  
Dose Response ◽  
Subcutaneous Injection ◽  
Response Relationship ◽  
Dose Response Relationship

ABSTRACT The stimulating action of testosterone on the chick's comb can be inhibited by the subcutaneous injection of 0.1 mg of norethisterone or Ro 2-7239 (2-acetyl-7-oxo-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene), 0.5 mg of cortisol or progesterone, and by 4.5 mg of Mer-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol). No dose response relationship could be established. Norethisterone was the most active anti-androgen by this test.

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