Nasal Provocation Test is Useful for Discriminating Allergic, Nonallergic, and Local Allergic Rhinitis

2015 ◽  
Vol 29 (4) ◽  
pp. e100-e104 ◽  
Author(s):  
Tae Young Jang ◽  
Young Hyo Kim
Author(s):  
Su-Jong Kim ◽  
Jee Won Moon ◽  
Heung-Man Lee

Local allergic rhinitis (LAR) is a localized nasal allergic response in the absence of systemic atopy. The symptoms, duration, severity, and comorbidities of LAR are similar to those of allergic rhinitis. Although pathophysiology of LAR is not fully understood, in some patients specific IgE can be demonstrated in the nasal secretions. The diagnosis currently relies on the positive results of nasal provocation test. Nasal provocation test has shown high sensitivity and specificity with safety, and is considered as the gold standard. LAR patients benefit from the same therapeutic strategies as allergic rhinitis patients, including the avoidance of allergen exposure and the pharmacotherapy. Effectiveness and safety of allergen immunotherapy open a window of treatment opportunity in LAR. This review provides a current update on LAR.


2015 ◽  
Vol 115 (5) ◽  
pp. 385-390.e1 ◽  
Author(s):  
Frédéric de Blay ◽  
Virginie Doyen ◽  
Céline Lutz ◽  
Julien Godet ◽  
Cindy Barnig ◽  
...  

2014 ◽  
Vol 133 (2) ◽  
pp. AB81
Author(s):  
Frederic de Blay ◽  
Celine Lutz ◽  
Mael Bellier ◽  
Jean Jacques Braun ◽  
Brigitte Sbinne

10.5772/39069 ◽  
2012 ◽  
Author(s):  
Graa Loureiro ◽  
Beatriz Tavares ◽  
Daniel Machado ◽  
Celso Pereir

2008 ◽  
Vol 139 (1) ◽  
pp. 120-123 ◽  
Author(s):  
Young Hyo Kim ◽  
Tae Yong Yang ◽  
Dong Youl Lee ◽  
Kook Jin Ko ◽  
Seung Ho Shin ◽  
...  

2015 ◽  
Vol 6 (2) ◽  
pp. ar.2015.6.0122 ◽  
Author(s):  
Celso Eduardo Olivier ◽  
Daiana Guedes Pinto Argentão ◽  
Regiane Patussi dos Santos Lima ◽  
Mariana Dias da Silva ◽  
Raquel Acácia Pereira Gonçalves dos Santos ◽  
...  

Background Asymptomatic sensitization is a frequent condition that must be considered before the indication of allergic-specific immunotherapy. Objective The aim of this study was to appreciate and correlate the local and spirometric changes elicited by the allergen-specific nasal provocation test (NPT) to define practical and feasible guidelines for the allergist/immunologist to demonstrate specific respiratory hyperresponsiveness before the indication of allergic-specific immunotherapy. Methods A total of 172 subjects (children and adults) with a diagnosis of allergic rhinitis were submitted to flow-volume spirometry immediately before and after the NPT performed with Dermatophagoides antigens. The differences between the pre- and postspirometric estimated values of peak expiratory flow rate (PEFdif%), forced expiratory volume in 1 second (FEV1dif%), and forced vital capacity (FVCdif%) were correlated with the results of the nasal provocation test symptom score (NPT-SS). Results There were 119 subjects (69%) with NPT-SS > 2. Among these patients who were reactive, the mean NPT-SS was 6.3. The Spearman's correlation between PEFdif% and NPT-SS was r = −0.44 (p = 0.01); the Spearman's correlation between FEV1dif% and NPT-SS was r = −0.22 (p = 0.01), and the Spearman's correlation between FVCdif% and NPT-SS was r = −0.21 (p = 0.04). Conclusion The combined utilization of the allergen-specific NPT-SS with the spirometry (or PEF meter) is a safe methodology to evaluate allergen-specific nasal and bronchial hyperresponsiveness (which sometimes acts as a bronchial provocation test) in patients with allergic rhinitis and asthma due to hypersensitivity who are candidates for allergen-specific immunotherapy.


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