Plasma metanephrins are associated with myocardial hypertrophy and cardiac diastolic function in patients with essential hypertension

Purpose: To explore the association between the sympathetic system activity and myocardial hypertrophy in patients with essential hypertension. Methods: A total of 84 essential hypertension inpatients were recruited from China-Japan Friendship Hospital between January 2019 and September 2019. Activity of sympathetic system was quantified by plasma metanephrines (MNs) levels. All subjects received an echocardiographic test. Results: The interventricular septum thickness (diastolic), left ventricular mass and left ventricular mass index increased significantly with plasma MNs quartiles, and plasma MNs were positively and significantly correlated with early diastolic transmitral flow velocity to early diastolic mitral annular tissue velocity. Conclusions: In patients with essential hypertension, high level of plasma MNs associates with left ventricular hypertrophy and impaired diastolic function.