Microchannel heat exchangers offer the potential for high heat transfer coefficients; however, implementation challenges must be addressed to realize this potential. Maldistribution of phases among the microchannels and the changing phase velocities associated with phase change present design challenges. Flow maldistribution and oscillatory instabilities can affect transfer rates and pressure drops. In condensers, evaporators, absorbers, and desorbers, changing phase velocities can change prevailing flow regimes from favorable to unfavorable. Geometries with serpentine passages containing pin fins can be configured to maintain favorable flow regimes throughout the component for phase-change heat and mass transfer applications. Due to the possibility of continuous redistribution of the flow across the pin fins along the flow direction, maldistribution can also be reduced. These features enable high heat transfer coefficients, thereby achieving considerable compactness. The characteristics of two-phase flow through a serpentine passage with micro-pin fin arrays with diameter 350 μm and height 406 μm are investigated. An air–water mixture is used to represent two-phase flow through the serpentine test section, and flow features are investigated using high-speed photography. Improved flow distribution is observed in the serpentine geometry. Distinct flow regimes, different from those observed in microchannels, are also established. Void fraction and interfacial area along the length of the serpentine passages are compared with the corresponding values for microchannels. A model developed for the two-phase frictional pressure drops across this serpentine micro-pin fin geometry predicts experimental values with a mean absolute error (MAE) of 7.16%.