scholarly journals Extradural thoracic nerve root hemangioblastoma approached by a combined posterior thoracic spine and video-assisted thoracoscopic surgery: A case report

2022 ◽  
Vol 13 ◽  
pp. 10
Author(s):  
Diogo Roque ◽  
Daniel Cabral ◽  
Cristina Rodrigues ◽  
Nuno Simas
Keyword(s):  
Nerve Root ◽  
Thoracoscopic Surgery ◽  
Arterial Embolization ◽  
Surgical Excision ◽  
Cord Compression ◽  
Spinal Root ◽  
Von Hippel Lindau ◽  
Von Hippel Lindau Disease ◽  
Video Assisted Thoracoscopic Surgery ◽  
Complete Tumor

Background: Hemangioblastomas commonly occur in the posterior fossa and are typically attributed to sporadic or familial Von Hippel–Lindau disease. Spinal hemangioblastomas, found in 7–10% of patients, are usually located within the cord (i.e., intramedullary). Here, a 58-year-old male presented with a purely extradural hemangioblastoma involving a spinal root that was surgically excised. Case Description: A 58-year-old male was admitted with a progressive paraparesis and incomplete sensory deficit. The magnetic resonance imaging documented a solid dumbbell-shaped lesion that extended through the left T3-T4 foramen resulting in nerve root and spinal cord compression. Following arterial embolization and lesion excision by both neurosurgeons and thoracic surgeons, the patient’s deficits improved. The postoperative computed tomography scan documented complete tumor removal, and the neuropathology revealed a hemangioblastoma. Conclusion: Here, we describe a 58-year-old male with a purely extradural thoracic foraminal T3-T4 dumbbell-shaped hemangioblastoma successfully treated by both embolization and surgical excision.

scholarly journals Sacral hemangioblastoma in a patient with von Hippel–Lindau disease

2003 ◽  
Vol 15 (2) ◽  
pp. 1-4 ◽  
Author(s):  
Ryszard M. Pluta ◽  
Scott D. Wait ◽  
John A. Butman ◽  
Kathleen A. Leppig ◽  
Alexander O. Vortmeyer ◽  
...  
Keyword(s):  
Nerve Root ◽  
Histopathological Diagnosis ◽  
Resonance Imaging ◽  
Nerve Roots ◽  
Von Hippel Lindau ◽  
Sacral Nerve ◽  
Left Lower Extremity ◽  
History Of ◽  
Von Hippel Lindau Disease

Hemangioblastomas are histologically benign neoplasms that occur sporadically or as part of von Hippel–Lindau disease. Hemangioblastomas may occur anywhere along the neuraxis, but sacral hemangioblastomas are extremely rare. To identify features that will help guide the operative and clinical management of these lesions, the authors describe the management of a large von Hippel–Lindau disease–associated sacral hemangioblastoma and review the literature. The authors present the case of a 38-year-old woman with von Hippel–Lindau disease and a 10-year history of progressive back pain, as well as left lower-extremity pain and numbness. Neurological examination revealed decreased sensation in the left S-1 and S-2 dermatomes. Magnetic resonance imaging demonstrated a large enhancing lesion in the sacral region, with associated erosion of the sacrum. The patient underwent arteriography and embolization of the tumor and then resection. The histopathological diagnosis was consistent with hemangioblastoma and showed intrafascicular tumor infiltration of the S-2 nerve root. At 1-year follow-up examination, pain had resolved and numbness improved. Sacral nerve root hemangioblastomas may be safely removed in most patients, resulting in stabilization or improvement in symptomatology. Generally, hemangioblastomas of the sacral nerve roots should be removed when they cause symptoms. Because they originate from the nerve root, the nerve root from which the hemangioblastoma originates must be sacrificed to achieve complete resection.

Papillary Cystadenoma of the Epididymis

2010 ◽  
Vol 134 (4) ◽  
pp. 630-633 ◽  
Author(s):  
Karen J. Odrzywolski ◽  
Sanjay Mukhopadhyay
Keyword(s):  
Renal Cell Carcinoma ◽  
Hypoxia Inducible Factor ◽  
Benign Neoplasm ◽  
Surgical Excision ◽  
Precursor Lesions ◽  
Adult Males ◽  
Von Hippel Lindau ◽  
Immunohistochemical Markers ◽  
Von Hippel Lindau Disease ◽  
Papillary Cystadenoma

Abstract Papillary cystadenoma is a rare benign neoplasm of the epididymis, occurring mainly in young adult males. More than one-third of the cases reported in the literature have occurred in patients with von Hippel-Lindau disease. Conversely, epididymal nodules presumed to be papillary cystadenomas are found in one-third of males with von Hippel-Lindau disease. The association is stronger for bilateral tumors. The pathogenesis involves loss of the von Hippel-Lindau gene resulting in overexpression of the angiogenic protein “hypoxia-inducible factor.” Papillary cystadenoma is of mesonephric derivation. It originates in the efferent ductules of the head of the epididymis in the form of tiny precursor lesions. Histologically, papillary cystadenoma is characterized by cystic spaces with intracystic papillary projections lined by clear cells, with a resultant resemblance to renal cell carcinoma. Immunohistochemical markers may facilitate the distinction between the 2 tumors. Treatment consists of surgical excision and the prognosis is excellent.

Lumbar nerve root hemangioblastoma and iliac bone cyst in a patient with Von Hippel-Lindau disease

2016 ◽  
Vol 16 (1) ◽  
pp. e27-e29 ◽  
Author(s):  
Zafer Orkun Toktaş ◽  
Akın Akakın ◽  
Deniz Konya ◽  
Yavuz Furuncuoglu ◽  
Mustafa Kemal Demir ◽  
...  
Keyword(s):  
Nerve Root ◽  
Bone Cyst ◽  
Iliac Bone ◽  
Von Hippel Lindau ◽  
Lumbar Nerve Root ◽  
Von Hippel Lindau Disease

scholarly journals Sporadic Intradural Extramedullary Hemangioblastoma of Cauda Equina with Large Peritumoral Cyst—A Rare Presentation

2022 ◽  
Author(s):  
Pushpa B. Thippeswamy ◽  
Dilip C. R. Soundararajan ◽  
Ríshi M. Kanna ◽  
Venkata S. Kuna ◽  
Shanmuganathan Rajasekaran
Keyword(s):  
Cauda Equina ◽  
Surgical Excision ◽  
Vascular Tumor ◽  
Spinal Tumors ◽  
Rare Presentation ◽  
Von Hippel Lindau ◽  
Drop Metastasis ◽  
Neural Axis ◽  
Von Hippel Lindau Disease ◽  
Intradural Extramedullary

AbstractCauda equina intradural tumors commonly reported include ependymoma, schwannoma, neurofibroma, meningioma, and drop metastasis. Hemangioblastoma of the neural axis is a rare benign vascular tumor comprising only 1.6 to 6.4% of spinal tumors, and are usually associated with Von-Hippel Lindau disease. Sporadic intradural extramedullary hemangioblastoma involving cauda equina is very rare with only countable reports, and the presence of peritumoral cyst has been reported only once. We report one such case of hemangioblastoma with a large peritumoral cyst, which was diagnosed radiologically and confirmed by histopathology following surgical excision. Pertinent radiological characteristics, diagnostic clues, treatment, and surgical outcomes are discussed.

The yield and cost of radiological screening in von Hippel-Lindau disease

2019 ◽  
Author(s):  
Timothy McMillan ◽  
Anju Sahdev ◽  
Jane Evanson ◽  
Lorraine McAndrew ◽  
Lee Martin ◽  
...  
Keyword(s):  
Von Hippel Lindau ◽  
Von Hippel Lindau Disease

A novel heterozygous mutation in exon 3 of VHL gene leading to Von Hippel-Lindau disease in a Turkish family

2019 ◽  
Author(s):  
Ozge Tasgin Yildirim ◽  
Ismail Yildiz ◽  
Fatih Horozoglu ◽  
Aysun Gonen ◽  
Cenk Murat Yazici ◽  
...  
Keyword(s):  
Heterozygous Mutation ◽  
Vhl Gene ◽  
Von Hippel Lindau ◽  
Turkish Family ◽  
Von Hippel Lindau Disease

Myasthenia gravis miatt végzett három különböző típusú csecsemőmirigy-eltávolítás sebészeti és korai neurológiai eredményei

2015 ◽  
Vol 68 (6) ◽  
pp. 219-224
Author(s):  
Aurél Ottlakán ◽  
Tibor Géczi ◽  
Balázs Pécsy ◽  
Bernadett Borda ◽  
Judit Lantos ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Thoracoscopic Surgery ◽  
Extended Thymectomy ◽  
Video Assisted ◽  
Video Assisted Thoracoscopic Surgery

Absztrakt Célkitűzés: A myasthenia gravis (MG) kezelésében számos nyitott, illetve minimálisan invazív thymectomia ismert. A tanulmány ugyanazon intézeten belül a transsternalis (TS), illetve kétféle minimálisan invazív thymectomia (video-assisted thoracoscopic extended thymectomy – VATET; unilateral video-assisted thoracoscopic surgery – UL-VATS) eredményeit hasonlítja össze. Anyag és módszerek: Három különböző időintervallumban 71 betegnél történt thymectomia MG miatt (60 nő, 11 férfi): 23 transsternalis thymectomia (1995. január–2004. szeptember), 22 VATET (2004. szeptember – 2009. augusztus) és 26 UL-VATS thymectomia (2009. szeptember – 2011. december). Az eredmények értékelésénél a műtéti idő, MG-hez társuló neurológiai és a műtét utáni sebészi szövődmények, valamint az MG státuszában az egyéves utánkövetéskor észlelt neurológiai változások szerepeltek. Eredmények: Perioperatív mortalitás nem fordult elő. A műtéti idő 112, 211, 116 perc (p = 0,001), a kórházi napok száma: 8,9, 5,6 és 4 nap (p = 0,001) volt a TS-, VATET- és UL-VATS-csoportban. Az MG-hez kapcsolódó postoperativ neurológiai szövődmények 21,7%, 18,2% és 7,7% (p = 0,365) értékeket mutattak. A sebészi szövődmény 4,3%, 13,7%, 0% (p = 0,118) volt. Az MG tüneteinek javulása 91,3%, 94,7%, 87,5% (p = 0,712), míg komplett remisszió 13%, 10,5%, 11,5% (p = 0,917) volt a TS-, VATET- és UL-VATS-csoportokban. Következtetések: A műtéti idő, valamint a kórházban eltöltött napok száma UL-VATS esetében volt a legrövidebb. A kisebb sebészi beavatkozáshoz alacsonyabb sebészi, illetve MG-s neurológiai szövődmények társultak. Az MG-tünetek javulásában mindhárom módszernél kiváló eredményt értek el.

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