Human Hepatocyte Suspensions as a Model to Assess Reversible and Time-Dependent Inhibition of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A4

2016 ◽  
Author(s):  
George Zhang
Keyword(s):  
Human Hepatocyte ◽  
Time Dependent ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

Reversible and time-dependent inhibition (TDI) of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 in human hepatocyte suspensions by model inhibitors

2017 ◽  
Vol 32 (1) ◽  
pp. S57-S58
Author(s):  
J. George Zhang ◽  
Thuy Ho ◽  
Reena Patel ◽  
Sarah K. Trisdale ◽  
Tim Creegan ◽  
...  
Keyword(s):  
Human Hepatocyte ◽  
Time Dependent ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

Statistical Methods for Analysis of Time-Dependent Inhibition of Cytochrome P450 Enzymes

2012 ◽  
Vol 40 (12) ◽  
pp. 2289-2296 ◽  
Author(s):  
Phillip Yates ◽  
Heather Eng ◽  
Li Di ◽  
R. Scott Obach
Keyword(s):  
Cytochrome P450 ◽  
Statistical Methods ◽  
Time Dependent ◽  
Cytochrome P450 Enzymes ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

Combination of GSH Trapping and Time-Dependent Inhibition Assays as a Predictive Method of Drugs Generating Highly Reactive Metabolites

2011 ◽  
Vol 39 (7) ◽  
pp. 1247-1254 ◽  
Author(s):  
Shintaro Nakayama ◽  
Hideo Takakusa ◽  
Akiko Watanabe ◽  
Yoshihiro Miyaji ◽  
Wataru Suzuki ◽  
...  
Keyword(s):  
Time Dependent ◽  
Reactive Metabolites ◽  
Predictive Method ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

Effect of Solvents on the Time-Dependent Inhibition of CYP3A4 and the Biotransformation of AZD3839 in Human Liver Microsomes and Hepatocytes

2012 ◽  
Vol 41 (1) ◽  
pp. 159-169 ◽  
Author(s):  
Jenny Aasa ◽  
Yin Hu ◽  
Göran Eklund ◽  
Anders Lindgren ◽  
Pawel Baranczewski ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Time Dependent ◽  
Effect Of Solvents ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

Time-Dependent Inhibition of Oxotremorine-Induced Cerebral Hyperemia by N ω -Nitro- l -Arginine in Cats

Stroke ◽  
1995 ◽  
Vol 26 (11) ◽  
pp. 2160-2165 ◽  
Author(s):  
Charisse S. Tietjen ◽  
Jeffrey R. Kirsch ◽  
Nathalie Clavier ◽  
Richard J. Traystman
Keyword(s):  
Time Dependent ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

scholarly journals Numerical Analysis of Time-Dependent Inhibition by MDMA

2019 ◽  
Vol 48 (1) ◽  
pp. 1-7
Author(s):  
John T. Rodgers ◽  
Jeffrey P. Jones
Keyword(s):  
Numerical Analysis ◽  
Time Dependent ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition
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