scholarly journals Normothermic machine perfusion parameters correlate with early allograft function in DBD and DCD kidney transplants

2018 ◽  
Author(s):  
Sarah Hosgood
Keyword(s):  
Machine Perfusion ◽  
Kidney Transplants ◽  
Allograft Function ◽  
Normothermic Machine Perfusion

scholarly journals Continuous Normothermic Machine Perfusion for Renovation of Extended Criteria Donor Livers Without Recooling in Liver Transplantation: A Pilot Experience

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhitao Chen ◽  
Xitao Hong ◽  
Shanzhou Huang ◽  
Tielong Wang ◽  
Yihao Ma ◽  
...  
Keyword(s):  
Acute Hepatic Failure ◽  
Meld Score ◽  
Decompensated Cirrhosis ◽  
Machine Perfusion ◽  
Donor Liver ◽  
Extended Criteria Donor ◽  
Allograft Function ◽  
Normothermic Machine Perfusion ◽  
End Stage ◽  
Early Allograft Dysfunction

Background: Ischemia injury affects the recovery of liver allograft function. We propose a novel technique aimed at avoiding a second ischemic injury: transplanting an extended criteria donor (ECD) liver directly under normothermic machine perfusion (NMP) without recooling. We studied two cases to evaluate the efficacy and safety of this technique.Methods: The perioperative characteristics and postoperative outcomes of two recipients of ECD livers were analyzed. Both transplantations were performed with continuous normothermic machine perfusion without recooling.Result: In case 1, the cause of donor death was anoxia, and the donor liver had hypernatremia before procurement. The recipient was diagnosed with decompensated cirrhosis. His model for end-stage liver disease (MELD) score was 38. In case 2, the donor liver was from a donor after cardiac death (DCD), and the donor had elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. The recipient was diagnosed with acute hepatic failure. His MELD score was 35. Both donor livers were maintained under NMP and then transplanted without recooling. The peak ALT and AST levels after surgery were 452 and 770 U/L in case 1 and 100 and 592 U/L in case 2. Neither early allograft dysfunction (EAD) nor primary graft non-function (PNF) was present in these two cases.Conclusion: In conclusion, our results demonstrate that continuous NMP without recooling is efficacious and safe for LT with extended criteria donor livers. Further investigations of this technique will be performed to confirm these promising results.

scholarly journals Human liver stem cell‐derived extracellular vesicles reduce injury in a model of normothermic machine perfusion of rat livers previously exposed to a prolonged warm ischemia

2021 ◽  
Vol 34 (9) ◽  
pp. 1607-1617
Author(s):  
Nicola De Stefano ◽  
Victor Navarro‐Tableros ◽  
Dorotea Roggio ◽  
Alberto Calleri ◽  
Federica Rigo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Extracellular Vesicles ◽  
Human Liver ◽  
Warm Ischemia ◽  
Machine Perfusion ◽  
Normothermic Machine Perfusion ◽  
Rat Livers

scholarly journals Point‐of‐Care Assessment of DCD Livers During Normothermic Machine Perfusion in a Nonhuman Primate Model

2021 ◽  
Author(s):  
Samuel J. Kesseli ◽  
Jared N. Gloria ◽  
Nader Abraham ◽  
Samantha E. Halpern ◽  
Greta N. Cywinska ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Point Of Care ◽  
Machine Perfusion ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Care Assessment ◽  
Normothermic Machine Perfusion

scholarly journals Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration

Hepatology ◽  
2019 ◽  
Vol 70 (2) ◽  
pp. 682-695 ◽  
Author(s):  
Wayel Jassem ◽  
Emmanuel Xystrakis ◽  
Yasmeen G. Ghnewa ◽  
Muhammed Yuksel ◽  
Oltin Pop ◽  
...  
Keyword(s):  
Machine Perfusion ◽  
Proinflammatory Responses ◽  
Normothermic Machine Perfusion

Hyperspectral imaging for ex-vivo organ characterization during normothermic machine perfusion

2018 ◽  
Vol 17 (2) ◽  
pp. e767 ◽  
Author(s):  
W. Markgraf ◽  
M.W.W. Janssen ◽  
J. Lilienthal ◽  
P. Feistel ◽  
C. Thiele ◽  
...  
Keyword(s):  
Hyperspectral Imaging ◽  
Ex Vivo ◽  
Machine Perfusion ◽  
Normothermic Machine Perfusion

scholarly journals A novel, customized 3D-printed perfusion chamber for normothermic machine perfusion of the kidney

2018 ◽  
Vol 32 (1) ◽  
pp. 107-109 ◽  
Author(s):  
Ahmer Hameed ◽  
Suat Dervish ◽  
Natasha Rogers ◽  
Henry Pleass ◽  
Wayne Hawthorne
Keyword(s):  
Machine Perfusion ◽  
Perfusion Chamber ◽  
Normothermic Machine Perfusion ◽  
3D Printed

scholarly journals Porcine Liver Normothermic Machine Perfusion: Methodological Framework and Potential Pitfalls

2021 ◽  
Vol 8 (1) ◽  
pp. e1276
Author(s):  
Nicholas Gilbo ◽  
Tine Wylin ◽  
Veerle Heedfeld ◽  
Ina Jochmans ◽  
Jacques Pirenne ◽  
...  
Keyword(s):  
Machine Perfusion ◽  
Methodological Framework ◽  
Porcine Liver ◽  
Normothermic Machine Perfusion

scholarly journals The 24-hour normothermic machine perfusion of discarded human liver grafts

2017 ◽  
Vol 23 (2) ◽  
pp. 207-220 ◽  
Author(s):  
Thomas Vogel ◽  
Jens G. Brockmann ◽  
Alberto Quaglia ◽  
Alireza Morovat ◽  
Wayel Jassem ◽  
...  
Keyword(s):  
Human Liver ◽  
Machine Perfusion ◽  
Normothermic Machine Perfusion

MicroRNA antagonist therapy during normothermic machine perfusion of donor kidneys

2021 ◽  
Author(s):  
ER Thompson ◽  
A Sewpaul ◽  
R Figuereido ◽  
L Bates ◽  
SJ Tingle ◽  
...  
Keyword(s):  
Machine Perfusion ◽  
Antagonist Therapy ◽  
Normothermic Machine Perfusion
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