Initial lower threshold was a risk factor of severe adverse reaction during oral immunotherapy for cow’s milk anaphylaxis

2018 ◽  
Author(s):  
Sakura  Sato
Keyword(s):  
Adverse Reaction ◽  
Risk Factor ◽  
Oral Immunotherapy ◽  
Lower Threshold ◽  
Cow’S Milk ◽  
Severe Adverse Reaction ◽  
Cow's Milk

Soy Formula Doesn't Help Colic

PEDIATRICS ◽  
1983 ◽  
Vol 71 (2) ◽  
pp. 299-300
Author(s):  
LASSE LOTHE ◽  
TOR LINDBERG ◽  
IRÉNE JAKOBSSON
Keyword(s):  
Adverse Reaction ◽  
Soy Protein ◽  
Milk Proteins ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Cow's Milk ◽  
Cow’S Milk Proteins

In Reply.— We fully agree with LeBlanc that there was no significant improvement when infants with colic were given a soy protein-based formula. As pointed out in the "Discussion," as many as 53% of the infants showed an adverse reaction to soy (corresponding figure for cow's milk formula was 71%). We also emphasized that these figures must be interpreted with caution. In fact, soy protein-based formula was a bad choice as placebo. A placebo substance should be a substance of no importance as an allergen in infancy and soy protein has been shown to be as antigenic as cow's milk proteins (Eastham EJ, et al: J Pediatr 1978;93:561).

scholarly journals Oral immunotherapy for IgE-mediated cow’s milk allergy in children: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Lujing Tang ◽  
Yu Yu ◽  
Xiangyuan Pu ◽  
Jie Chen
Keyword(s):  
Meta Analysis ◽  
Oral Immunotherapy ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Control Group ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Statistical Heterogeneity ◽  
Ige Mediated

Background: Cow’s milk allergy(CMA) is the most common allergy in infants that decreases the quality of life of patients and their families. Standard treatment for CMA is the strict avoidance of milk, new treatment strategies such as oral immunotherapy (OIT) have been sought for patients with CMA . We aimed to assess the clinical efficacy and safety of OIT in the treatment of children with IgE-mediated cow’s milk allergy (IMCMA). Methods: We searched all randomized controlled trials (RCTs) in which OIT is used to treat children with IMCMA from 5 international electronic databases. We estimated a pooled relative ratio (RR) for each outcome using a Mantel-Haenzel fixed-effect model if statistical heterogeneity was low. Results: Eleven studies were chosen for meta-analysis, including a total of 469 children (242 OIT, 227 control). 176 patients (72.7%) in the OIT were desensitized compared to 49 patients in the control group (RR 7.35, 95%CI 2.82-19.13, p<0.0001). The desensitization effect of OIT was particularly significant in children over 3 years old (RR 18.05, 95%CI 6.48-50.26, p<0.00001). Although adverse effects were common, they usually involved mild reactions, but epinephrine use was more common in the OIT group (RR 7.69, 95%CI 2.16-27.33, p<0.002). Conclusion: OIT can lead to desensitization in the majority of individuals with IMCMA, especially in patients over 3-years old. A major problem of OIT is the frequency of adverse events, although most are mild. OIT may be an alternative treatment in the future.

A Partially Blind Study

PEDIATRICS ◽  
1983 ◽  
Vol 71 (4) ◽  
pp. 667-668
Author(s):  
BRIAN FORSYTH
Keyword(s):  
Adverse Reaction ◽  
Blind Study ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Double Blind Study ◽  
Infantile Colic ◽  
Double Blind ◽  
Cow's Milk ◽  
Blinded Study

To the Editor.— I would like to suggest that the article entitled: "Cow's Milk Formula as a Cause of Infantile Colic: A Double-Blind Study"1 would be better entitled: Infantile Colic and Confusion with Milk Formulas: A Partially Blinded Study. The authors of the article suggest that their results demonstrate that infantile colic was "cow's milk dependent in 71% of the infants in the study" and "53% of these infants also showed an adverse reaction to soy." With this, I disagree.

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