scholarly journals 02 / Differential response of internal carotid artery blood flow to cardiac output changes.

Author(s):  
Maria Skytioti
2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Ryota Asahara ◽  
Kei Ishii ◽  
Tsubasa Izaki ◽  
Sunao Iwaki ◽  
Hidehiko Komine

2017 ◽  
Vol 313 (6) ◽  
pp. H1155-H1161 ◽  
Author(s):  
Shigehiko Ogoh ◽  
Gilbert Moralez ◽  
Takuro Washio ◽  
Satyam Sarma ◽  
Michinari Hieda ◽  
...  

The effect of acute increases in cardiac contractility on cerebral blood flow (CBF) remains unknown. We hypothesized that the external carotid artery (ECA) downstream vasculature modifies the direct influence of acute increases in heart rate and cardiac function on CBF regulation. Twelve healthy subjects received two infusions of dobutamine [first a low dose (5 μg·kg−1·min−1) and then a high dose (15 μg·kg−1·min−1)] for 12 min each. Cardiac output, blood flow through the internal carotid artery (ICA) and ECA, and echocardiographic measurements were performed during dobutamine infusions. Despite increases in cardiac contractility, cardiac output, and arterial pressure with dobutamine, ICA blood flow and conductance slightly decreased from resting baseline during both low- and high-dose infusions. In contrast, ECA blood flow and conductance increased appreciably during both low- and high-dose infusions. Greater ECA vascular conductance and corresponding increases in blood flow may protect overperfusion of intracranial cerebral arteries during enhanced cardiac contractility and associated increases in cardiac output and perfusion pressure. Importantly, these findings suggest that the acute increase of blood perfusion attributable to dobutamine administration does not cause cerebral overperfusion or an associated risk of cerebral vascular damage. NEW & NOTEWORTHY A dobutamine-induced increase in cardiac contractility did not increase internal carotid artery blood flow despite an increase in cardiac output and arterial blood pressure. In contrast, external carotid artery blood flow and conductance increased. This external cerebral blood flow response may assist with protecting from overperfusion of intracranial blood flow.


1994 ◽  
Vol 71 (1) ◽  
pp. F53-F54 ◽  
Author(s):  
V H Mandelbaum ◽  
C D Guajardo ◽  
M Nelle ◽  
O Linderkamp

Haemodilution in nine neonates resulted in significant mean (SEM) decrease of packed cell volume (0.67 (0.01) to 0.55 (0.01)) and increases in cardiac output (250 (16) to 308 (25) ml/min/kg) and blood flow velocities of the internal carotid artery and the coeliac artery (+20%). However, red cell flows in the aorta, carotid and coeliac arteries did not change during haemodilution, thereby indicating that haemodilution did not improve oxygen transport.


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