Derivatives of 1,3,5-triazine, a new class of 5-ht6 receptor ligands, can reverse memory impairments in novel object recognition test in rats

2018 ◽  
Author(s):  
Magdalena Jastrzębska-Więsek ◽  
Anna Partyka
Keyword(s):  
Object Recognition ◽  
Recognition Test ◽  
Novel Object Recognition ◽  
Receptor Ligands ◽  
Object Recognition Test ◽  
Novel Object ◽  
Memory Impairments ◽  
New Class ◽  
Novel Object Recognition Test ◽  
Derivatives Of

scholarly journals NAAG peptidase inhibitors and deletion of NAAG peptidase gene enhance memory in novel object recognition test

2013 ◽  
Vol 701 (1-3) ◽  
pp. 27-32 ◽  
Author(s):  
Karolina J. Janczura ◽  
Rafal T. Olszewski ◽  
Tomasz Bzdega ◽  
Dean J. Bacich ◽  
Warren D. Heston ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Test ◽  
Novel Object Recognition ◽  
Object Recognition Test ◽  
Novel Object ◽  
Peptidase Inhibitors ◽  
Novel Object Recognition Test ◽  
Naag Peptidase

scholarly journals Galanin (1–15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats

2019 ◽  
Vol 155 ◽  
pp. 104-112 ◽  
Author(s):  
Antonio Flores-Burgess ◽  
Carmelo Millón ◽  
Belen Gago ◽  
Laura García-Durán ◽  
Noelia Cantero-García ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Object Recognition ◽  
Recognition Test ◽  
Fluoxetine Interaction ◽  
Novel Object Recognition ◽  
The Novel ◽  
Object Recognition Test ◽  
Novel Object ◽  
Novel Object Recognition Test

scholarly journals Social State Influences Memory in Novel Object Recognition Test Through Oxidative Stress Balance in Male Rats

2018 ◽  
Vol 8 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Hamidreza Famitafreshi ◽  
Morteza Karimian
Keyword(s):  
Oxidative Stress ◽  
Prefrontal Cortex ◽  
Object Recognition ◽  
Recognition Test ◽  
Memory Performance ◽  
Novel Object Recognition ◽  
Object Recognition Test ◽  
Novel Object ◽  
Novel Object Recognition Test ◽  
Nitrite Nitrate

Objective:Social isolation is associated with adverse effects on brain functions. According to previous studies, the reduction of oxidative stress improves cognitive functions. Memory performance is dependent on hippocampus and prefrontal function. The aim of this study is to show that impairment of memory in object recognition test in isolation state is accompanied by deregulation of oxidative stress balance in related areas.Methods and Materials:In this study, 14 male Sprague-Dawley rats were randomly divided into two groups as follows: social and isolation. Socialization and isolation plus one week of acclimatization occurred for fourteen days. At the end of the study, after performing behavioral test, (novel object recognition test) rats were anesthetized and sacrificed. After preparation of tissues in controlled condition, oxidative stress status in hippocampus and prefrontal cortex for Malondialdehyde (MDA), glutathione and nitrite/nitrate was assessed.Results:MDA in the hippocampus and prefrontal cortex was higher in isolated rats compared to social rats. Glutathione and nitrite/nitrate in the hippocampus and prefrontal cortex were lower in isolated rats compared to social rats. Memory performance in novel object recognition test both in short term and long term was better in social rats.Conclusion:Memory performance in novel object recognition test is influenced by social and oxidative stress status. So improving memory is possible through socialization and improvement of antioxidant status.

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