Iridium-Catalyzed Asymmetric α-Allylic Alkylation of Amides using Vinyl Azide as Amide Enolate Surrogate
Keyword(s):
Among the unstabilized enolates used as nucleophile in iridium-catalyzed asymmetric allylic alkylation reactions, amide enolates are least explored. Vinyl azides are now employed as amide enolate surrogate for the first time in Ir-catalyzed asymmetric allylic alkylation with branched allylic alcohols as the allylic electrophile. Competing reaction pathways are suppressed through systematic tuning of steric and electronic properties of vinyl azide to effect α-allylic alkylation of secondary acetamides with high atom-economy, exclusive branched selectivity and moderate to excellent enantioselectivity.<br>
2020 ◽
2019 ◽
Vol 23
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pp. 1168-1213
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2007 ◽
Vol 72
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pp. 2842-2850
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2015 ◽
Vol 54
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pp. 12645-12648
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2018 ◽
Vol 16
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pp. 7717-7724
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2008 ◽
Vol 19
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pp. 454-458
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