dual catalysis
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ACS Catalysis ◽  
2022 ◽  
pp. 1677-1685
Anon Bunrit ◽  
Teera Butburee ◽  
Meijiang Liu ◽  
Zhipeng Huang ◽  
Keerati Meeporn ◽  

Shruti Rajput ◽  
Ramandeep Kaur ◽  
Nidhi Jain

Directing group assisted decarboxylative ortho-benzoylation of N-aryl-7-azaindoles with α-keto acids has been achieved by synergistic visible light promoted photoredox and palladium catalysis. The approach tenders rapid entry to aryl ketone...

Chao Li ◽  
Duo-Duo Hu ◽  
Ruoxing Jin ◽  
Bing-Bing Wu ◽  
Cheng-Yu Wang ◽  

A photoredox/nickel-catalyzed selective 1,4-arylsulfonation of 1,3-enynes to access structurally diverse sulfone-containing allenes has been established. This radical cascade transformation featured with easy manipulation, mild conditions, low catalyst loading, broad substrate...

2021 ◽  
Vol 12 (1) ◽  
Zachary S. Clauss ◽  
Casia L. Wardzala ◽  
Austin E. Schlirf ◽  
Nathaniel S. Wright ◽  
Simranpreet S. Saini ◽  

AbstractThe cellular glycocalyx and extracellular matrix are rich in glycoproteins and proteoglycans that play essential physical and biochemical roles in all life. Synthetic mimics of these natural bottlebrush polymers have wide applications in biomedicine, yet preparation has been challenged by their high grafting and glycosylation densities. Using one-pot dual-catalysis polymerization of glycan-bearing α-amino acid N-carboxyanhydrides, we report grafting-from glycopolypeptide brushes. The materials are chemically and conformationally tunable where backbone and sidechain lengths were precisely altered, grafting density modulated up to 100%, and glycan density and identity tuned by monomer feed ratios. The glycobrushes are composed entirely of sugars and amino acids, are non-toxic to cells, and are degradable by natural proteases. Inspired by native lipid-anchored proteoglycans, cholesterol-modified glycobrushes were displayed on the surface of live human cells. Our materials overcome long-standing challenges in glycobrush polymer synthesis and offer new opportunities to examine glycan presentation and multivalency from chemically defined scaffolds.

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