scholarly journals Advantages of control over the course of hypertension disease with the fixed combination of amlodipine and perindoprilе arginin

2018 ◽  
Vol 15 (4) ◽  
pp. 17-23
Author(s):  
O D Alyokhina ◽  
I V Chesnokova
Keyword(s):  
Quality Of Life ◽  
Blood Pressure ◽  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Fixed Combination ◽  
Enzyme Inhibitor ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitor ◽  
Target Organs

Background. To improve the prognosis and quality of life of patients with essential hypertension, it is necessary to search for combinations of antihypertensive drugs that can affect all parameters of blood pressure (BP) and restrict remodeling of target organs. Aim. To study the effect of free and fixed combination of angiotensin converting enzyme inhibitor (perindopril arginine) and dihydropyridine calcium antagonist (amlodipine) on BP parameters, target organs damage criteria and quality of life of hypertensive patients. Materials and methods. The study included 92 patients suffering from arterial hypertension (AH) II and III stages. The 1st group included patients who received within 12 months treatment in a free combination of an angiotensin converting enzyme inhibitor (perindopril arginine) and amlodipine, in the 2nd group - in a fixed combination. The changes in BP indices were compared, including BP variability, criteria for target organs remodeling and quality of life assessed using the SF-36 questionnaire. Results. The results of office and 24-hour BP monitoring at the study stages demonstrated better control of all BP indices in patients of the 2nd group, reduction of short-, medium- and long-term BP variability. Against the background of treatment with a fixed combination of amlodipine and perindopril arginine, there were significantly more significant changes in 3 parameters of target organs remodeling: glomerular filtration rate, microalbuminuria, ankle-brachial index, and restoration of diastolic function of the left ventricle. At the same time, different positive dynamics of the quality of life indicators of patients of both study groups were noted. Conclusion. Fixed combined full-dose antihypertensive therapy with amlodipine and perindopril arginine allows achieving BP targets (including BP variability) in the majority of patients with AH II and III stages with high and very high risk of cardiovascular complications. High adherence to therapy allowed not only to maintain all parameters of blood pressure at the target level within a year, but also significantly improve the parameters of target organs remodeling and the quality of life of patients

scholarly journals The Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker on the Outcome of Hospitalization of Patients With Hypertension and COVID-19

2021 ◽  
Vol 34 (6) ◽  
pp. 665-666
Author(s):  
Xi-jing Zhuang ◽  
Wen-jun Wang ◽  
Xiao-hui Zhao ◽  
Wei Wei ◽  
Wei-wang Fan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Creatine Kinase ◽  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Angiotensin Receptor Blocker ◽  
Enzyme Inhibitor ◽  
Converting Enzyme ◽  
Angiotensin Receptor ◽  
Converting Enzyme Inhibitor ◽  
Group A

Abstract Background To study the effect of angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) on the outcome of hospitalization in patients with hypertension and novel coronavirus disease 2019 (COVID-19). Methods A retrospective analysis was performed in 202 COVID-19 patients who were hospitalized in Thunder-God Hospital, Wuhan from 12 February 2020 to 30 March 2020. According to whether taking ACEI or ARB, 67 (33.0%) patients with hypertension were divided into 3 groups: A, patients received ACEI or ARB after admission (n = 22); B, patients received ACEI or ARB before admission but interrupted after admission (n = 24); and C, patients were not treated with ACEI or ARB before or after admission (n = 21). Changes of therapeutic indicators in all groups of patients and their application relationship with ACEI/ARB were compared and analyzed. Results There were no significant differences in age, gender, blood pressure, underlying disease severity, or serum biochemical indicators (ALT, LDH, creatinine, and creatine kinase levels) at admission among 3 groups (all P > 0.05). During hospitalization, there were no significant differences in COVID-19-related treatment, oxygen use, hospital mortality, recovery and discharge rate, or days of throat swab nucleic acid turning negative among 3 groups (all P > 0.05). The proportion of calcium channel blocker in groups B and C was higher than group A (95.8% and 85.7% vs. 40.9%, P < 0.01), but there was no significant difference in blood pressure or compliance rates at discharge (P > 0.05). Group A, B, and C patients were hospitalized for 27.4 ± 6.4, 30.0 ± 8.8, and 30.1 ± 9.3 days, respectively (all P > 0.05). Compared with admission values, there were no significant differences in serum ALT, LDH, creatinine, or creatine kinase levels among all 3 groups during hospitalization (all P > 0.05). Conclusions ACEI or ARB has no significant effect on the outcome of hospitalization in patients with hypertension and COVID-19.

Captopril in Refractory Malignant Hypertension

1980 ◽  
Vol 14 (5) ◽  
pp. 373-374 ◽  
Author(s):  
Anthony R. Zappacosta ◽  
Peter H. Vlasses ◽  
Roger K. Ferguson
Keyword(s):  
Blood Pressure ◽  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Enzyme Inhibitor ◽  
Antihypertensive Agents ◽  
Malignant Hypertension ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitor

The blood pressure of a 36-year-old male with malignant hypertension could not be controlled adequately by as many as eight concurrent oral and parenteral antihypertensive agents administered over a three-week period. These agents included the potent vasodilating agent minoxidil. Only after the initiation of captopril, an oral angiotensin converting enzyme inhibitor, was his blood pressure normalized.

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