We study semi-invariant Riemannian submersions from a nearly Kaehler manifold to a Riemannian manifold. It is well known that the vertical distribution of a Riemannian submersion is always integrable therefore, we derive condition for the integrability of horizontal distribution of a semi-invariant Riemannian submersion and also investigate the geometry of the foliations. We discuss the existence and nonexistence of semi-invariant submersions such that the total manifold is a usual product manifold or a twisted product manifold. We establish necessary and sufficient conditions for a semi-invariant submersion to be a totally geodesic map. Finally, we study semi-invariant submersions with totally umbilical fibers.