PERBEDAAN NILAI RASIO NEUTROFIL-LIMFOSIT PRE DAN POST OPERASI CORONARY ARTERY BYPASS GRAFTING ON-PUMP TERHADAP KEJADIAN ACUTE KIDNEY INJURY DAN NON-ACUTE KIDNEY INJURY

Acute Kidney Injury (AKI) adalah sindrom kompleks yang ditandai dengan penurunan fungsi ginjal. Pada penelitian ini, rasio neutrofil-limfosit (RNL) yang tinggi dikaitkan dengan perkembangan AKI setelah Coronary Artery Bypass Grafting On-Pump (CABG on-pump). Penggunaan RNL sebagai parameter yang tersedia dengan mudah untuk mendeteksi pasien yang berisiko terkena AKI. Tujuan penelitian untuk mengetahui perbedaan nilai RNL pasca operasi CABG on-pump terhadap kejadian AKI dan Non-AKI. Penelitian ini merupakan penelitian analitik dengan pendekatan cross sectional. Semua data klinis preoperative dan postoperative diambil sebagai data sekunder dari rekam medik pasien yang menjalani CABG di Rumah Sakit Umum Daerah Abdul Wahab Sjahranie (RSUD AWS) Samarinda periode Januari 2017-Desember 2020. Penelitian menggunakan uji statistik dengan Mann-Whitney dan Uji Regresi. Hasil penelitian ini ditemukan 41,1% dari 56 sampel mengalami AKI. Hasil didapatkan bahwa terdapat perbedaan nilai RNL pasca operasi pada sampel AKI dan Non-AKI dengan nilai p=0,008. Peningkatan RNL ≥ 10 kali risiko sebesar 6,352 kali lipat.

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Faculty Opinions recommendation of Prevention of acute kidney injury by erythropoietin in patients undergoing coronary artery bypass grafting: a pilot study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1162244.622723 ◽

2009 ◽

Author(s):

Robert Anderson

Keyword(s):

Acute Kidney Injury ◽

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Pilot Study ◽

Coronary Artery Bypass ◽

Artery Bypass ◽

Kidney Injury ◽

Bypass Grafting ◽

Artery Bypass Grafting

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Faculty Opinions recommendation of Preoperative anemia in patients undergoing coronary artery bypass grafting predicts acute kidney injury.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3713962.3438062 ◽

2010 ◽

Author(s):

John Augoustides ◽

Tygh Wyckoff

Keyword(s):

Acute Kidney Injury ◽

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Coronary Artery Bypass ◽

Artery Bypass ◽

Kidney Injury ◽

Bypass Grafting ◽

Preoperative Anemia ◽

Artery Bypass Grafting

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Association between preoperative level of hemoglobin A1c and the incidence of acute kindey injury after coronary artery bypass grafting surgery: a cohort study

Ain-Shams Journal of Anesthesiology ◽

10.1186/s42077-021-00161-7 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Ghada Mohamed Samir ◽

Omar Mohamed Ali Mohamed Omar ◽

Madiha Metwally Zidan ◽

Hazem Abd El Rahman Fawzy ◽

Marwa Mamdouh Mohamed El Far

Keyword(s):

Acute Kidney Injury ◽

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Coronary Artery Bypass ◽

Hemoglobin A1c ◽

Artery Bypass ◽

Kidney Injury ◽

P Value ◽

Bypass Grafting ◽

Artery Bypass Grafting

Abstract Background The development of acute kidney injury (AKI) is an important indicator of clinical outcomes after cardiac surgery. Elevated preoperative hemoglobin A1c level may be associated with acute kidney injury in patients undergoing coronary artery bypass grafting. This study will investigate the association of preoperative HbA1c levels with AKI after isolated coronary artery bypass grafting (CABG). Results Forty patients undergoing elective CABG were enrolled in this cohort study. Patients are divided into 2 equal groups who underwent isolated coronary artery bypass grafting (CABG): patients with preoperative HbA1c 5.7–6.4% (group A) (prediabetics) and patients with preoperative HbA1c > or = 6.5% (group B) (diabetics). Acute kidney injury according to the Kidney Disease: Improving Global Outcomes criteria developed in 11 patients (27.5%). There was a significant difference between the two groups as regards postoperative urinary NGAL, creatinine level on the 1st day, creatinine level on the 2nd day, urine output on the 1st day, and urine output on the 2nd day (p value was 0.001, 0.002, 0.006, 0.0002, and 0.012 respectively). Postoperative ICU stay duration was statistically significant in the diabetic group (P value 0.009). The need for renal replacement therapy was higher in the diabetic group, but it was not statistically significant between the two groups. Roc analysis shows AUC 0.922 with a significant p value (< 0.0001) and cut of value (≥ 7) with sensitivity 81.82 and specificity 93.10. Conclusion This study revealed that elevated preoperative HbA1c level above 7% showed an increase in incidence of post CABG acute kidney injury along with increase length of postoperative ICU stay.

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