Effects of Recombinant Interferon-Gamma and Interleukin-2 on the Generation of Lymphokine-Activated Killer Cells in Vitro

1990 ◽  
Vol 8 (5) ◽  
pp. 493-500 ◽  
Author(s):  
Harry W. Findley ◽  
Sherif Nasr ◽  
Zeinab Afify ◽  
Robert Hnath ◽  
Kathy Waldrep ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Interleukin 2 ◽  
Lymphokine Activated Killer Cells ◽  
Killer Cells ◽  
Recombinant Interferon

scholarly journals Role of prolactin in the in vitro development of interleukin‐2‐driven anti‐tumoural lymphokine‐activated killer cells

Immunology ◽  
1996 ◽  
Vol 89 (4) ◽  
pp. 619-626 ◽  
Author(s):  
L. MATERA ◽  
G. BELLONE ◽  
J.‐J. LEBRUN ◽  
P. A. KELLY ◽  
E. L. HOOGHE PETERS ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
Lymphokine Activated Killer Cells ◽  
Killer Cells ◽  
In Vitro Development ◽  
Vitro Development

In vivo administration of low-dose human interleukin-2 induces lymphokine-activated killer cells for enhanced cytolysis in vitro

1991 ◽  
Vol 132 (2) ◽  
pp. 277-284 ◽  
Author(s):  
Gerald E. Hancock ◽  
Anthony Molloy ◽  
A.B. Birhane Kale ◽  
Rolf Kiessling ◽  
Marijke Becx-Bleumink ◽  
...  
Keyword(s):  
Low Dose ◽  
Interleukin 2 ◽  
Lymphokine Activated Killer Cells ◽  
Killer Cells ◽  
In Vivo Administration

Liver Metastases from Gastric Carcinoma: Report of a Patient Treated with Adoptive Immunotherapy (Tumor-Infiltrating Lymphocytes plus Interleukin-2 and Subsequently Local-Regional Lymphokine-Activated Killer Cells plus inTerleukin-2)

1995 ◽  
Vol 81 (6) ◽  
pp. 445-449 ◽  
Author(s):  
Laura Fabbri ◽  
Ruggero Ridolfi ◽  
Angela Riccobon ◽  
Roberta Maltoni ◽  
Emanuela Flamini ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Liver Metastases ◽  
Adoptive Immunotherapy ◽  
Specific Activity ◽  
Interleukin 2 ◽  
Tumor Infiltrating Lymphocytes ◽  
Lymphokine Activated Killer Cells ◽  
Killer Cells ◽  
Infiltrating Lymphocytes

A 37-year-old patient with liver metastases from gastric cancer was treated with a double adoptive immunotherapy regimen comprising tumor-infiltrating lymphocytes plus interleukin-2 and subsequently local-regional lymphokine-activated killer cells plus interleukin-2 because of an extremely high in vitro cytotoxic specific activity on established gastric cancer cell lines. The necrosis verified in the center of the hepatic metastasis would appear to demonstrate treatment efficacy, but no clinical response was seen. In vitro cytotoxicity data alone are insufficient to predict the clinical efficacy of adoptive immunotherapy.

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