Sequence Analysis of Human Endogenous Retrovirus Clone 4-1 in Systemic Lupus Erythematosus

Autoimmunity ◽  
2001 ◽  
Vol 33 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Hitoshi Ogasawara ◽  
Takashi Hishikawa ◽  
Iwao Sekigawa ◽  
Hiroshi Hashimoto ◽  
Naoki Yamamoto ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Sequence Analysis ◽  
Lupus Erythematosus ◽  
Endogenous Retrovirus ◽  
Human Endogenous Retrovirus ◽  
Systemic Lupus

Polymorphic genotypes of the HRES-1 human endogenous retrovirus locus correlate with systemic lupus erythematosus and autoreactivity

1999 ◽  
Vol 49 (10) ◽  
pp. 829-834 ◽  
Author(s):  
Claudio Magistrelli ◽  
Ella Samoilova ◽  
Rajeev K. Agarwal ◽  
Katalin Banki ◽  
Pasquale Ferrante ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Endogenous Retrovirus ◽  
Human Endogenous Retrovirus ◽  
Systemic Lupus

scholarly journals DNA methylation of human endogenous retrovirus in systemic lupus erythematosus

2013 ◽  
Vol 58 (5) ◽  
pp. 241-249 ◽  
Author(s):  
Jeerawat Nakkuntod ◽  
Pattadon Sukkapan ◽  
Yingyos Avihingsanon ◽  
Apiwat Mutirangura ◽  
Nattiya Hirankarn
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Methylation ◽  
Lupus Erythematosus ◽  
Endogenous Retrovirus ◽  
Human Endogenous Retrovirus ◽  
Systemic Lupus

scholarly journals Antibodies against human endogenous retrovirus K102 envelope activate neutrophils in systemic lupus erythematosus

2021 ◽  
Vol 218 (7) ◽  
Author(s):  
Maria Tokuyama ◽  
Bronwyn M. Gunn ◽  
Arvind Venkataraman ◽  
Yong Kong ◽  
Insoo Kang ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Immune Complex ◽  
Lupus Erythematosus ◽  
Envelope Protein ◽  
Endogenous Retrovirus ◽  
Innate Immune ◽  
Human Endogenous Retrovirus ◽  
Systemic Lupus ◽  
Extracellular Traps ◽  
Immune Complex Formation

Neutrophil activation and the formation of neutrophil extracellular traps (NETs) are hallmarks of innate immune activation in systemic lupus erythematosus (SLE). Here we report that the expression of an endogenous retrovirus (ERV) locus ERV-K102, encoding an envelope protein, was significantly elevated in SLE patient blood and correlated with autoantibody levels and higher interferon status. Induction of ERV-K102 in SLE negatively correlated with the expression of epigenetic silencing factors. Anti-ERV-K102 IgG levels in SLE plasma correlated with higher interferon stimulated gene expression, and further promoted enhanced neutrophil phagocytosis of ERV-K102 envelope protein through immune complex formation. Finally, phagocytosis of ERV-K102 immune complexes resulted in the formation of NETs consisting of DNA, neutrophil elastase, and citrullinated histone H3. Together, we identified an immunostimulatory ERV-K envelope protein that in an immune complex with SLE IgG is capable of activating neutrophils.

Sequence Analysis of TNFRSF13b, Encoding TACI, in Patients with Systemic Lupus Erythematosus

2007 ◽  
Vol 27 (4) ◽  
pp. 372-377 ◽  
Author(s):  
Ulrich Salzer ◽  
Jennifer Birmelin ◽  
Chiara Bacchelli ◽  
Torsten Witte ◽  
Ulrike Buchegger-Podbielski ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Sequence Analysis ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Antibody against envelope protein from human endogenous retrovirus activates neutrophils in systemic lupus erythematosus

2019 ◽  
Author(s):  
Maria Tokuyama ◽  
Bronwyn M. Gunn ◽  
Arvind Venkataraman ◽  
Yong Kong ◽  
Insoo Kang ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Complex Formation ◽  
Immune Complex ◽  
Lupus Erythematosus ◽  
Envelope Protein ◽  
Endogenous Retrovirus ◽  
Neutrophil Activation ◽  
Systemic Lupus ◽  
Interferon Signature ◽  
Immune Complex Formation

AbstractNeutrophil activation and the formation of neutrophil extracellular trap (NET) are hallmarks of innate immune activation in systemic lupus erythematosus (SLE) and contribute to the systemic interferon signature. Here we report that the expression of an endogenous retrovirus (ERV) locus ERV-K102, encoding an envelope protein, was significantly elevated in SLE patient blood and was correlated with higher interferon status. Induction of ERV-K102 expression most strongly correlated with reduced transcript levels of epigenetic silencing factors. SLE IgG promoted phagocytosis of ERV-K102 envelope protein by neutrophils through immune complex formation. ERV immune complex phagocytosis resulted in subsequent NET formation consisting of DNA, neutrophil elastase, and citrullinated histone H3. Finally, analysis of anti-ERV-K102 IgG in SLE patients showed that IgG2 likely mediates this effect. Together, we identified an immunostimulatory ERV-K envelope protein elevated in SLE that may be a target of SLE IgG and able to promote neutrophil activation.eTOC summaryUsing ERVmap, the authors determined that the expression of ERV-K102 locus was elevated in SLE patient blood and correlated with the interferon signature. The envelope protein encoded by this locus activates human neutrophils through immune complex formation with SLE IgG.

scholarly journals Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus

2008 ◽  
Vol 58 (2) ◽  
pp. 532-540 ◽  
Author(s):  
Rudolf Pullmann ◽  
Eduardo Bonilla ◽  
Paul E. Phillips ◽  
Frank A. Middleton ◽  
Andras Perl
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Endogenous Retrovirus ◽  
Systemic Lupus

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

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