Laila Abdullah S. Alanazi
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Abdullah Mohammed A. AL Madshush
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Omniyyah Mohammed S. Alatawi
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Asmaa Hamed M. Albuhairy
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Jomana Khalid M. Aljohani
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Idiopathic inflammatory myopathies (IIMs) includes an unusual group of acute, chronic, and subacute developed diseases of skeletal muscle characterized by moderate to severe muscle weakness and inflammation.Polymyositis is generally considered to be a prototypic T cell-mediated autoimmune myopathy, while DM was traditionally associated with a humoral-driven microangiopathy, though the putative autoantibodies and their targets have yet to be identified, and there is increasing evidence implicating the type I interferon pathway in the pathogenesis of the disease. Women between the ages of 50 and 70 are the most typically affected. Proximal muscular weakness is the most common clinical symptom. Inflammatory arthritis, Raynaud's phenomenon, myocarditis, and interstitial lung disease are all examples of extramuscular involvement. In this review, we overview updates in diagnosis and managements of polymyositis.
Autoantibody Specificities and Type I Interferon Pathway Activation in Idiopathic Inflammatory Myopathies
