scholarly journals Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

2013 ◽  
Vol 44 (1) ◽  
pp. 64-82 ◽  
Author(s):  
Clifford R. Elcombe ◽  
Richard C. Peffer ◽  
Douglas C. Wolf ◽  
Jason Bailey ◽  
Remi Bars ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Mode Of Action ◽  
Liver Toxicity ◽  
Constitutive Androstane Receptor ◽  
Relevance Analysis

Classifying chemical mode of action using gene networks and machine learning: A case study with the herbicide linuron

2013 ◽  
Vol 8 (4) ◽  
pp. 263-274 ◽  
Author(s):  
Anna Ornostay ◽  
Andrew M. Cowie ◽  
Matthew Hindle ◽  
Christopher J.O. Baker ◽  
Christopher J. Martyniuk
Keyword(s):  
Machine Learning ◽  
Mode Of Action ◽  
Gene Networks

An evaluation of the mode of action framework for mutagenic carcinogens case study: Cyclophosphamide

2008 ◽  
Vol 49 (2) ◽  
pp. 117-131 ◽  
Author(s):  
Nancy McCarroll ◽  
Nagalakshmi Keshava ◽  
Michael Cimino ◽  
Margaret Chu ◽  
Kerry Dearfield ◽  
...  
Keyword(s):  
Mode Of Action

scholarly journals Xenobiotic Stress Induces Hepatomegaly and Liver Tumors via the Nuclear Receptor Constitutive Androstane Receptor

2005 ◽  
Vol 19 (6) ◽  
pp. 1646-1653 ◽  
Author(s):  
Wendong Huang ◽  
Jun Zhang ◽  
Michele Washington ◽  
Jun Liu ◽  
John M. Parant ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Liver Tumors ◽  
Constitutive Androstane Receptor ◽  
Xenobiotic Stress

scholarly journals Uptake and Metabolism of Tritiated 17ß-Oestradiol and Oestrone by Rabbit Uterine Tissue in vitro

1974 ◽  
Vol 27 (2) ◽  
pp. 137 ◽  
Author(s):  
RG Gabb ◽  
GM Stone
Keyword(s):  
Nuclear Receptor ◽  
Mode Of Action ◽  
Nuclear Extract ◽  
Lower Proportion ◽  
The Other ◽  
Uterine Tissue ◽  
Uptake And Metabolism

To determine whether the established capability of rabbit uterine tissue to interconvert 17 p-oestradiol and oestrone might have some effect on the mode of action of the oestrogens in this organ, the in vitro interconversion of [3H]-17p-oestradiol and [3H]oestrone by rabbit endometrial and myometrial tissue was investigated and the identity of radiometabolites in 'soluble, 'mitochondrial-microsomal' a'nd 'nuclear' preparations was studied. Both endometrial and myometrial tissue were found to be capable of oxidoreduction of the oestrogens, the equilibrium of the reaction favouring the reduction of oestrone. Irrespective of the tissue--steroid combination studied, the greater part of the radioactivity in all fractions was associated with 17p-oestradiol. The relative proportions of [3Hl-17p-oestradiol and [3H]oestrone varied between fractions, the nuclear preparation consistently showing a lower proportion of oestrone than the other fractions. Sephade<c fractionation of a 0'4M KCl 'nuclear extract' revealed that proportionately less oestrone than 17p-oestradiol was bound to the nuclear 'receptor'. These findings provide further evidence for 17p-oestradiol being the ovarian oestrogen which is active in the uterus, and suggest a role for uterine oxidoreduction of oestrogens in the control exercised over this organ by these steroids.

scholarly journals The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

2009 ◽  
Vol 284 (38) ◽  
pp. 25984-25992 ◽  
Author(s):  
Jie Gao ◽  
Jinhan He ◽  
Yonggong Zhai ◽  
Taira Wada ◽  
Wen Xie
Keyword(s):  
Insulin Sensitivity ◽  
Nuclear Receptor ◽  
Constitutive Androstane Receptor
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