Lipid Peroxidation, Tissue Necrosis, and Metabolic and Mechanical Recovery of Isolated Reperfused Rat Heart as a Function of Increasing Ischemia

1998 ◽  
Vol 28 (1) ◽  
pp. 25-37 ◽  
Author(s):  
Barbara Tavazzi ◽  
Donato Di Pierro ◽  
Marco Bartolini ◽  
Mario Marino ◽  
Stefanla Distefano ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Rat Heart ◽  
Tissue Necrosis ◽  
Mechanical Recovery

Magnolol and honokiol isolated from magnolia officinalis protect rat heart mitochondria against lipid peroxidation

1994 ◽  
Vol 47 (3) ◽  
pp. 549-553 ◽  
Author(s):  
Yu-Chiang Lo ◽  
Teng Che-Ming ◽  
Chen Chieh-Fu ◽  
Chen Chien-Chih ◽  
Hong Chuang-Ye
Keyword(s):  
Lipid Peroxidation ◽  
Rat Heart ◽  
Heart Mitochondria ◽  
Rat Heart Mitochondria ◽  
Magnolia Officinalis

Effects of Cyclosporin and Cremophor on Working Rat Heart and Incidence of Myocardial Lipid Peroxidation

Pharmacology ◽  
1996 ◽  
Vol 52 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Etienne Tatou ◽  
Claude Mossiat ◽  
Véronique Maupoil ◽  
François Gabrielle ◽  
Michel David ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Rat Heart ◽  
Working Rat Heart

Enzymatic defenses of the rat heart against lipid peroxidation

1997 ◽  
Vol 97 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Hector Molina ◽  
Miriam Garcı́a
Keyword(s):  
Lipid Peroxidation ◽  
Rat Heart

scholarly journals Celecoxib Decreases Mitochondrial Complex IV Activity and Induces Oxidative Stress in Isolated Rat Heart Mitochondria: An Analysis for its Cardiotoxic Adverse Effect

2020 ◽  
Author(s):  
Saman Atashbar ◽  
Elham Mohammad Khanlou ◽  
Saleh Khezri ◽  
Peyman Kurdpour ◽  
Ahmad Salimi
Keyword(s):  
Lipid Peroxidation ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Mitochondrial Swelling ◽  
Heart Mitochondria ◽  
Isolated Mitochondria ◽  
Biochemical Assays ◽  
Ros Formation ◽  
Rat Heart Mitochondria ◽  
Isolated Rat

Abstract Background In spite of the cardiotoxic effect of selective cyclooxygenase-2 inhibitors, they are most widely used as anti-inflammatory and analgesic drugs. Today, valdecoxib and rofecoxib have been withdrawn on the market but celecoxib remains. In this study, we focused on an analysis of celecoxib toxic effects on isolated mitochondrial. Methods isolated rat heart mitochondria were obtained using differential centrifugation. Using flowcytometry and biochemical assays we searched succinate dehydrogenases (SDH), mitochondrial membrane potential (MMP), reactive oxygen species (ROS) formation, mitochondrial swelling, lipid peroxidation and mitochondrial complexes activity in rat heart isolated mitochondria. Results In here our results indicated a significant decrease in activity of complexes IV after exposure with celecoxib (16 µg/ml). This decrease in activity of complexes IV is paralleled by the MMP collapse, ROS formation, mitochondrial swelling and lipid peroxidation. Conclusion For the first time, this introductory study has showed a significant decrease in activity of complexes IV and mitochondrial dysfunction after exposure with celecoxib in rat heart isolated mitochondria.

Ultrastructural effects of lipid peroxidation on the cardiac sarcolemma of the isolated rat heart

1990 ◽  
Vol 48 (3) ◽  
pp. 264-265
Author(s):  
T. Oguro ◽  
T. Onodera ◽  
M. Ashraf
Keyword(s):  
Lipid Peroxidation ◽  
Rat Heart ◽  
Cell Membranes ◽  
Isolated Rat Heart ◽  
Cell Membrane Permeability ◽  
Cardiac Cell ◽  
Tissue Slices ◽  
Cardiac Sarcolemma ◽  
Altered Cell ◽  
Isolated Rat

Previously we reported that hydrogen peroxide (H2O2) is primarily cytotoxic to the cardiac cell membranes presumably through lipid peroxidation (LP). However, the effect of LP on the altered cell membrane permeability remains unknown. In this study, we evaluated the ultrastructural effects of LP on the sarcolemma of the isolated rat heart using H2O2 and N,N’-diphenyl-p-phenylene diamine (DPPD), an antilipid peroxidative agent.The hearts were perfused with 300 μM H2O2 for 15 minutes. In the other experiment the hearts were perfused with 2.5 μM DPPD for 20 minutes prior to perfusion with H2O2 for 15 minutes. Coronary effluent was collected at the end of the equilibration period and during H2O2 treatment for malondialdehyde (MDA) determination. Two minutes prior to the termination of the experiment, horseradish peroxidase (HRP: 220 U/mg × 55 mg) was perfused to assess the enhanced permeability of the cell membranes. The tissue slices were incubated in Graham-Karnovsky medium for one hour followed by postfixation with buffered 1% OsO4.

The Inhibitory Effect of Tannins on Lipid Peroxidation of Rat Heart Mitochondria

1995 ◽  
Vol 47 (2) ◽  
pp. 138-142 ◽  
Author(s):  
CHUANG-YE HONG ◽  
CHEIN-PING WANG ◽  
SHIANG-SUO HUANG ◽  
FENG-LIN HSU
Keyword(s):  
Lipid Peroxidation ◽  
Rat Heart ◽  
Inhibitory Effect ◽  
Heart Mitochondria ◽  
Rat Heart Mitochondria

Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation

1981 ◽  
Vol 30 (20) ◽  
pp. 2797-2804 ◽  
Author(s):  
Edward G. Mimnaugh ◽  
Michael A. Trush ◽  
Theodore E. Gram
Keyword(s):  
Lipid Peroxidation ◽  
Rat Heart

scholarly journals Dehydro-flavonolignans from silymarin are potent inhibitors of lipid peroxidation in isolated respiring rat heart and liver mitochondria

2014 ◽  
Vol 1837 ◽  
pp. e63
Author(s):  
Martin Modrianský ◽  
Aleš Dvořák ◽  
David Biedermann ◽  
Vladimír Křen ◽  
Petr Ježek ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Rat Heart ◽  
Liver Mitochondria
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