The effects of cytochrome P450 induction by xenobiotics on endobiotic metabolism in pre-clinical safety studies

Toxicology Mechanisms and Methods ◽

10.3109/15376511003690307 ◽

2010 ◽

Vol 20 (4) ◽

pp. 159-166 ◽

Author(s):

David E. Amacher

Keyword(s):

Cytochrome P450 ◽

Clinical Safety ◽

Cytochrome P450 Induction ◽

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ICH GUIDANCE ON THE TIMING OF NON-CLINICAL SAFETY STUDIES and REMAINING PHARMACOKINETIC ISSUES

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.12.supplement_141 ◽

1997 ◽

Vol 12 (supplement) ◽

pp. 141-141

Author(s):

Hiroshi Mayahara

Keyword(s):

Clinical Safety ◽

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Whether cytochrome p450 induction accompanies glucuronosyl and glutathione transferase induction by isomers of dipyridyl appears unrelated to dose and iron chelation properties

Journal of Biochemical Toxicology ◽

10.1002/jbt.2570070205 ◽

1992 ◽

Vol 7 (2) ◽

pp. 81-85 ◽

Author(s):

Michael R. Franklin

Keyword(s):

Cytochrome P450 ◽

Glutathione Transferase ◽

Iron Chelation ◽

Cytochrome P450 Induction

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Cytochrome P450 induction as a biomarker: Induction of “P450E” (P450IA1) in winter flounder by 3,3′,4,4′-tetrachlorobiphenyl and by exposure to inducers in the field

Ecological Indicators ◽

10.1007/978-1-4615-4661-0_71 ◽

1992 ◽

pp. 1552-1553

Author(s):

E. Monosson ◽

J. J. Stegeman

Keyword(s):

Cytochrome P450 ◽

Winter Flounder ◽

Cytochrome P450 Induction

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Usefulness and limitations of mRNA measurement in HepaRG cells for evaluation of cytochrome P450 induction

Fundamental Toxicological Sciences ◽

10.2131/fts.7.9 ◽

2020 ◽

Vol 7 (1) ◽

pp. 9-14 ◽

Author(s):

Kenta Mizoi ◽

Yuuki Fukai ◽

Eiko Matsumoto ◽

Satoshi Koyama ◽

Seiichi Ishida ◽

...

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Induction ◽

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Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity

Drug Metabolism and Disposition ◽

10.1124/dmd.118.082875 ◽

2018 ◽

Vol 46 (11) ◽

pp. 1562-1571 ◽

Author(s):

Albert P. Li ◽

Novera Alam ◽

Kirsten Amaral ◽

Ming-Chih David Ho ◽

Carol Loretz ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Metabolism ◽

Experimental System ◽

Mucosal Epithelium ◽

Cytochrome P450 Induction

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Cytochrome P450 Induction

Enzyme Inhibition in Drug Discovery and Development ◽

10.1002/9780470538951.ch8 ◽

2010 ◽

pp. 265-314 ◽

Author(s):

Edward L. Lecluyse ◽

Michael W. Sinz ◽

Nicola Hewitt ◽

Stephen S. Ferguson ◽

Jasminder Sahi

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Induction

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CHAPTER 10. Cytochrome P450 Induction

10.1039/9781788016414-00198 ◽

2021 ◽

pp. 198-219

Author(s):

Hua Lv ◽

Wei Zhu ◽

Hong Shen

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Induction

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Determination of In Vitro Cytochrome P450 Induction Potential Using Cryopreserved Human Hepatocytes

Methods in Pharmacology and Toxicology - Cytochrome P450 ◽

10.1007/978-1-0716-1542-3_12 ◽

2021 ◽

pp. 193-215

Author(s):

Susan Wong

Keyword(s):

Cytochrome P450 ◽

Human Hepatocytes ◽

Cytochrome P450 Induction

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The endothelin receptor antagonist macitentan for the treatment of pulmonary arterial hypertension: A cross‐species comparison of its cytochrome P450 induction pattern

Pharmacology Research & Perspectives ◽

10.1002/prp2.619 ◽

2020 ◽

Vol 8 (4) ◽

Author(s):

Alexander Treiber ◽

Stephane Delahaye ◽

Swen Seeland ◽

Carmela Gnerre

Keyword(s):

Cytochrome P450 ◽

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Endothelin Receptor ◽

Species Comparison ◽

Induction Pattern ◽

Cytochrome P450 Induction ◽

Pulmonary Arterial ◽

Cross Species Comparison

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Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment

Drug Metabolism and Disposition ◽

10.1124/dmd.120.000055 ◽

2020 ◽

Vol 49 (1) ◽

pp. 94-110

Author(s):

Simon G. Wong ◽

Diane Ramsden ◽

Shannon Dallas ◽

Conrad Fung ◽

Heidi J. Einolf ◽

...

Keyword(s):

Risk Assessment ◽

Cytochrome P450 ◽

Drug Interaction ◽

Working Group ◽

Time Course ◽

Model Fitting ◽

Regulatory Agencies ◽

Cytochrome P450 Induction ◽

Drug Drug Interaction

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