Methods in Pharmacology and Toxicology - Cytochrome P450
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Published By Springer US

9781071615416, 9781071615423

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Cytochrome P450: In Vitro Methods and Protocols

Methods in Pharmacology and Toxicology - Cytochrome P450 ◽

10.1007/978-1-0716-1542-3_1 ◽

2021 ◽

pp. 1-25

Author(s):

Zhengyin Yan ◽

Gary W. Caldwell

Keyword(s):

Cytochrome P450 ◽

In Vitro Methods

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Cytochrome P450-Mediated Drug Bioactivation Assay: An Untargeted High Resolution Accurate Mass LC/MS Assay

Methods in Pharmacology and Toxicology - Cytochrome P450 ◽

10.1007/978-1-0716-1542-3_19 ◽

2021 ◽

pp. 307-318

Author(s):

Kevin M. Johnson

Keyword(s):

Cytochrome P450 ◽

High Resolution ◽

Accurate Mass ◽

High Resolution Accurate Mass

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Determination of In Vitro Cytochrome P450 Induction Potential Using Cryopreserved Human Hepatocytes

Methods in Pharmacology and Toxicology - Cytochrome P450 ◽

10.1007/978-1-0716-1542-3_12 ◽

2021 ◽

pp. 193-215

Author(s):

Susan Wong

Keyword(s):

Cytochrome P450 ◽

Human Hepatocytes ◽

Cytochrome P450 Induction

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Cytochrome P450 Gene Regulation: Reporter Assays to Assess Aryl Hydrocarbon Receptor (HLHE76, AhR) Activation and Antagonism

Methods in Pharmacology and Toxicology - Cytochrome P450 ◽

10.1007/978-1-0716-1542-3_10 ◽

2021 ◽

pp. 157-174

Author(s):

Marija Pinne ◽

Judy L. Raucy

Keyword(s):

Gene Regulation ◽

Cytochrome P450 ◽

Aryl Hydrocarbon Receptor ◽

Cytochrome P450 Gene ◽

P450 Gene ◽

Aryl Hydrocarbon ◽

Reporter Assays

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Cytochrome P450 Knock-Out Assay with Nonselective Inhibitors

Methods in Pharmacology and Toxicology - Cytochrome P450 ◽

10.1007/978-1-0716-1542-3_16 ◽

2021 ◽

pp. 261-275

Author(s):

Pasquale Carione ◽

Zhengyin Yan

Keyword(s):

Cytochrome P450 ◽

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Spectral Quantitation of Total Cytochrome P450 in Microsomes Using a Single-Beam Spectrophotometer

Methods in Pharmacology and Toxicology - Cytochrome P450 ◽

10.1007/978-1-0716-1542-3_4 ◽

2021 ◽

pp. 71-78

Author(s):

David M. Stresser

Keyword(s):

Cytochrome P450 ◽

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Cytochrome P450 Gene Regulation: Reporter Assays to Assess Pregnane X Receptor (PXR, NR1I2) Activation

Methods in Pharmacology and Toxicology - Cytochrome P450 ◽

10.1007/978-1-0716-1542-3_9 ◽

2021 ◽

pp. 141-155

Author(s):

Marija Pinne ◽

Judy L. Raucy

Keyword(s):

Gene Regulation ◽

Cytochrome P450 ◽

Pregnane X Receptor ◽

Cytochrome P450 Gene ◽

P450 Gene ◽

Reporter Assays

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Evaluation of Time-Dependent Cytochrome P450 Inhibition Using the Area Under the Curve Shift Method

Methods in Pharmacology and Toxicology - Cytochrome P450 ◽

10.1007/978-1-0716-1542-3_7 ◽

2021 ◽

pp. 107-119

Author(s):

Julie Huang

Keyword(s):

Cytochrome P450 ◽

Area Under The Curve ◽

Time Dependent ◽

Shift Method ◽

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Simultaneously Assessing Concentration Changes in 17 Biochemical Pathways as a Result of Drug Dosing and Cytochrome P450 and Non-cytochrome P450-Mediated Metabolism: A Quasi-Untargeted Metabolomics LC/MS Assay

Methods in Pharmacology and Toxicology - Cytochrome P450 ◽

10.1007/978-1-0716-1542-3_21 ◽

2021 ◽

pp. 341-357

Author(s):

John A. Masucci ◽

Feng Liang ◽

Kerem Bingol ◽

Vince Windisch ◽

Gary W. Caldwell

Keyword(s):

Cytochrome P450 ◽

Untargeted Metabolomics ◽

Drug Dosing ◽

Biochemical Pathways ◽

Concentration Changes

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Cytochrome P450-Mediated Metabolic Stability Assay in Liver Microsomes

Methods in Pharmacology and Toxicology - Cytochrome P450 ◽

10.1007/978-1-0716-1542-3_14 ◽

2021 ◽

pp. 229-242

Author(s):

Pasquale Carione

Keyword(s):

Cytochrome P450 ◽

Liver Microsomes ◽

Metabolic Stability

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