Differential expression of synapse associated protein 1 in cancers of the breast.

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding synapse associated protein 1, SYAP1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SYAP1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. SYAP1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SYAP1 in primary tumors of the breast was correlated with overall survival in patients with basal subtype cancer, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. SYAP1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of FXYD1 in cancers of the breast.

10.31219/osf.io/7gbuw ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding FXYD domain containing ion transport regulator 1, FXYD1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. FXYD1 mRNA was present at significantly reduced quantity in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of FXYD1 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancers, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. FXYD1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of phosphodiesterase 7B in cancers of the breast.

10.31219/osf.io/ymgu3 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding phosphodiesterase 7B, PDE7B, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PDE7B mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PDE7B in primary tumors of the breast was correlated with recurrence-free survival in patients with basal subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. PDE7B may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of M-phase phosphoprotein 9 in cancers of the breast.

10.31219/osf.io/b62ac ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

M Phase

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the M-phase phosphoprotein 9, MPHOSPH9, when comparing primary tumors of the breast to the tissue of origin, the normal breast. MPHOSPH9 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. MPHOSPH9 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of MPHOSPH9 in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. MPHOSPH9 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of ATPase Na+/K+ transporting subunit alpha 2 in cancers of the breast.

10.31219/osf.io/nf6qb ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding ATPase Na+/K+ transporting subunit alpha 2, ATP1A2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ATP1A2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ATP1A2 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with basal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. ATP1A2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of phosphodiesterase 2A in cancers of the breast.

10.31219/osf.io/x62kb ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding phosphodiesterase 2A, PDE2A, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PDE2A mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PDE2A in primary tumors of the breast was correlated with overall survival in patients with basal subtype breast cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. PDE2A may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of calcium and integrin binding 1 in cancers of the breast.

10.31219/osf.io/r9p8x ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding calcium and integrin binding 1, CIB1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CIB1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CIB1 in primary tumors of the breast was correlated with overall survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. CIB1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of ECT2 in cancers of the breast.

10.31219/osf.io/n8k3z ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding epithelial cell transforming 2, ECT2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ECT2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. ECT2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ECT2 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner, demonstrating a complex relationship between correlation of primary tumor expression with overall survival based on molecular subtype. ECT2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of chromobox 4 in cancers of the breast.

10.31219/osf.io/kdf7b ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding chromobox 4, CBX4, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CBX4 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CBX4 in primary tumors of the breast was correlated with overall survival in patients with luminal A type cancer, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. CBX4 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of spexin hormone in cancers of the breast.

10.31219/osf.io/jcva4 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding spexin hormone, SPX, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SPX mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SPX in primary tumors of the breast was correlated with distant metastasis-free survival in patients with basal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. SPX may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of HPSE2 in cancers of the breast.

10.31219/osf.io/astvr ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding heparanase 2 (inactive), HPSE2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. HPSE2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. HPSE2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of HPSE2 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. HPSE2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.