Differential expression of chromobox 4 in cancers of the breast.

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding chromobox 4, CBX4, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CBX4 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CBX4 in primary tumors of the breast was correlated with overall survival in patients with luminal A type cancer, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. CBX4 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of FXYD1 in cancers of the breast.

10.31219/osf.io/7gbuw ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding FXYD domain containing ion transport regulator 1, FXYD1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. FXYD1 mRNA was present at significantly reduced quantity in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of FXYD1 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancers, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. FXYD1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of sprouty RTK signaling antagonist 2 in cancers of the breast.

10.31219/osf.io/fnv4k ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Primary Tumors ◽

Rtk Signaling

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding sprouty RTK signaling antagonist 2, SPRY2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SPRY2 mRNA was present at significantly reduced quantity in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SPRY2 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancers, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. SPRY2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of ECT2 in cancers of the breast.

10.31219/osf.io/n8k3z ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding epithelial cell transforming 2, ECT2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ECT2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. ECT2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ECT2 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner, demonstrating a complex relationship between correlation of primary tumor expression with overall survival based on molecular subtype. ECT2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of KIAA0101 in cancers of the breast.

10.31219/osf.io/pkx9r ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding KIAA0101 when comparing primary tumors of the breast to the tissue of origin, the normal breast. KIAA0101 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. KIAA0101 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of KIAA0101 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with HER2+ and luminal A subtype cancer, but in a contrary manner, demonstrating a complex relationship between correlation of primary tumor expression with overall survival based on molecular subtype. KIAA0101 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of synapse associated protein 1 in cancers of the breast.

10.31219/osf.io/efwqd ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding synapse associated protein 1, SYAP1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SYAP1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. SYAP1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SYAP1 in primary tumors of the breast was correlated with overall survival in patients with basal subtype cancer, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. SYAP1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of mab-21 like 1 in cancers of the breast.

10.31219/osf.io/2gkba ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding mab-21 like 1, MAB21L1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. MAB21L1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. MAB21L1 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of MAB21L1 in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. MAB21L1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of defective in cullin neddylation 1 domain-containing 3 in cancers of the breast.

10.31219/osf.io/wgcqv ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding defective in cullin neddylation 1 domain-containing 3, DCUN1D3, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DCUN1D3 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of DCUN1D3 in primary tumors of the breast was correlated with recurrence-free survival in patients with basal, luminal A and luminal B subtype cancers, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. DCUN1D3 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of dystrophin in cancers of the breast.

10.31219/osf.io/yn2xe ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding dystrophin, DMD, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DMD was also differentially expressed in the tumor cells of patients with triple negative breast cancer. DMD mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of DMD in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. DMD may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of phosphodiesterase 7B in cancers of the breast.

10.31219/osf.io/ymgu3 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding phosphodiesterase 7B, PDE7B, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PDE7B mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PDE7B in primary tumors of the breast was correlated with recurrence-free survival in patients with basal subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. PDE7B may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of RHOJ in cancers of the breast.

10.31219/osf.io/d8cje ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding ras homolog family member J, RHOJ, when comparing primary tumors of the breast to the tissue of origin, the normal breast. RHOJ was also differentially expressed in the tumor cells of patients with triple negative breast cancer. RHOJ mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of RHOJ in primary tumors of the breast was correlated with recurrence-free survival in patients with luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. RHOJ may be of relevance to initiation, maintenance or progression of cancers of the female breast.