ZNF226 is over-expressed in brain metastatic breast cancer.

Zinc Finger Protein ◽

Differentially Expressed Gene ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Primary Tumors ◽

Finger Protein ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that zinc finger protein 248, encoded by ZNF248, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ZNF248 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of ZNF248 in primary tumors was significantly correlated with patient overall survival. Modulation of ZNF248 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

The gastrin releasing peptide, GRP, is differentially expressed in brain metastatic breast cancer.

10.31219/osf.io/5d2n9 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Brain Metastasis ◽

Microarray Data ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Primary Tumors ◽

Gastrin Releasing Peptide ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the gastrin releasing peptide, encoded by GRP, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Molecular functions of gastrin releasing peptide may be relevant to the processes by which tumor cells of the breast metastasize to the breast. Down-regulation of GRP may be an important event for metastasis of primary tumor-derived cancer cells to the brain in humans with metastatic breast cancer.

Versican (VCAN) is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

10.31219/osf.io/w6pyq ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Microarray Data ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Primary Tumors ◽

Tumor Tissues ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the chondroitin sulfate proteoglycan versican, encoded by VCAN, was among the genes whose expression was most different in the metastatic tumor tissues of patients with metastatic breast cancer, both in metastases to brain and to the lymph nodes when compared to primary tumors of the breast. Molecular functions (6-9) and down-regulation of VCAN may be important for metastasis of primary tumor-derived cancer cells to the lymph nodes and to the brain in humans with metastatic breast cancer, and suggests some level of common origin for metastases that reside in the lymph nodes and colonize the brain.

Dermatopontin is differentially expressed in brain metastatic breast cancer.

10.31219/osf.io/95jy7 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Brain Metastasis ◽

Microarray Data ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that dermatopontin, encoded by DPT, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. We observed a significant correlation between DPT expression in primary tumors of the breast and overall survival. Molecular functions of dermatopontin may be relevant to the processes by which tumor cells of the breast metastasize to the breast. Down-regulation of DPT may be an important event for metastasis of primary tumor-derived cancer cells to the brain in humans with metastatic breast cancer.

MPP6 is differentially expressed in human metastatic breast cancer, in the brain and in the lymph nodes.

10.31219/osf.io/f6tsu ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Brain Metastasis ◽

Microarray Data ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6), encoded by MPP6, was among the genes whose expression was most quantitatively different in the brain metastases of patients with metastatic breast cancer. MPP6 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of MPP6 in primary tumors was correlated with patient overall survival in patients with breast cancer. Modulation of MPP6 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain.

BMS1, ribosome biogenesis factor pseudogene 20, (BMS1P20) is differentially expressed in brain metastatic breast cancer.

10.31219/osf.io/yb8ts ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Brain Metastasis ◽

Microarray Data ◽

Ribosome Biogenesis ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that BMS1, ribosome biogenesis factor pseudogene 20, encoded by BMS1P20, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Molecular functions of BMS1P20 may be relevant to the processes by which tumor cells of the breast metastasize to the brain. Down-regulation of BMS1P20 may be an important event for metastasis of primary tumor-derived cancer cells to the brain in humans with metastatic breast cancer.

Microfibrillar-associated protein 5 (MFAP5) is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

10.31219/osf.io/53q7p ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Microarray Data ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Primary Tumors ◽

Tumor Tissues ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the microfibrillar-associated protein 5, encoded by MFAP5, was among the genes whose expression was most different in the metastatic tumor tissues of patients with metastatic breast cancer, both in metastases to brain and to the lymph nodes when compared to primary tumors of the breast. Molecular functions and down-regulation of MFAP5 may be important for metastasis of primary tumor-derived cancer cells to the lymph nodes and to the brain in humans with metastatic breast cancer, and suggests some level of common origin for metastases that reside in the lymph nodes and colonize the brain.

ADPGK is differentially expressed in brain metastatic human breast cancer.

10.31219/osf.io/65x4c ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Microarray Data ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that the ADP-dependent glucokinase, encoded by ADPGK, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ADPGK mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of ADPGK in primary tumors was significantly correlated with patient overall survival. Modulation of ADPGK expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

DR1 is differentially expressed in brain metastatic human breast cancer.

10.31219/osf.io/7yxj2 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Microarray Data ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that the down-regulator of transcription 1, TBP-binding (negative cofactor 2), encoded by DR1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. DR1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of DR1 in primary tumors was significantly correlated with patient post-progression survival. Modulation of DR1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

AIDA is a differentially expressed gene in human brain metastatic breast cancer.

10.31219/osf.io/z7qhb ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Brain Metastasis ◽

Microarray Data ◽

Differentially Expressed Gene ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that axin interactor, dorsalization associated, encoded by AIDA, was among the genes whose expression was most quantitatively different in the brain metastases of patients with metastatic breast cancer. AIDA mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of AIDA in primary tumors was significantly correlated with patient post-progression survival in patients with breast cancer. Modulation of AIDA expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain.