scholarly journals The faciogenital dysplasia gene FGD5 is differentially expressed in non-small cell lung cancer and associates with patient survival.

2020 ◽  
Author(s):  
Shahan Mamoor

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding the faciogenital dysplasia gene 5, FGD5, was among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. FGD5 expression was significantly decreased in NSCLC tumors as compared to the lung, and lower expression of FGD5 in patient tumors was significantly associated with worse overall survival. FGD5 may be important for initiation or progression of non-small cell lung cancer in humans.

2020 ◽  
Author(s):  
Shahan Mamoor

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that gene encoding glycoprotein M6A, GPM6A, was among those whose expression was most quantitatively different in human NSCLC tumors as compared to the lung. GPM6A expression levels were significantly decreased in NSCLC tumors as compared to the lung, and lower expression of GPM6A in patient tumors was significantly associated with worse overall survival. GPM6A may be important for initiation or progression of non-small cell lung cancer in humans.


2020 ◽  
Author(s):  
Shahan Mamoor

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding RhoJ, the ras homolog family member J (RhoJ) among those whose expression was most quantitatively different in human NSCLC tumors as compared to the lung. RhoJ expression levels were significantly decreased in NSCLC tumors as compared to the lung, and lower expression of RhoJ in patient tumors was significantly associated with worse overall survival. RhoJ may be important for initiation or progression of non-small cell lung cancer in humans.


2020 ◽  
Author(s):  
Shahan Mamoor

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding the myocardial zonula adherens protein, MYZAP, was among those whose expression was most different in human NSCLC tumors as compared to the lung. MYZAP expression levels were significantly decreased in NSCLC tumors as compared to the lung, and lower expression of MYZAP in patient tumors was significantly associated with worse overall survival. MYZAP may be important for initiation or progression of non-small cell lung cancer in humans.


2020 ◽  
Author(s):  
Shahan Mamoor

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding cadherin 5 (Cdh5) was among those whose expression was most quantitatively different in human NSCLC tumors as compared to the lung. Cdh5 expression levels were significantly decreased in NSCLC tumors as compared to the lung, and lower expression of Cdh5 in patient tumors was significantly associated with worse overall survival. Cdh5 may be important for initiation or progression of non-small cell lung cancer in humans.


2020 ◽  
Author(s):  
Shahan Mamoor

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4, 5) to identify differentially expressed genes in NSCLC. We found that the gene encoding aspartoacyclase (ASPA) was among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. ASPA expression was significantly decreased in NSCLC tumors as compared to the lung, and lower expression of ASPA in patient tumors was significantly associated with worse overall survival. ASPA may be important for initiation or progression of non-small cell lung cancer in humans.


2020 ◽  
Author(s):  
Shahan Mamoor

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding LRRC36 was among those whose expression was most different in human NSCLC tumors as compared to the lung. LRRC36 expression levels were significantly decreased in NSCLC tumors as compared to the lung, and lower expression of LRRC36 in patient tumors was significantly associated with worse overall survival. LRRC36 may be important for initiation or progression of non-small cell lung cancer in humans.


2020 ◽  
Author(s):  
Shahan Mamoor

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding the NCK associated protein 5, NCKAP5, was among those whose expression was most different in human NSCLC tumors as compared to the lung. NCKAP5 expression levels were significantly decreased in NSCLC tumors as compared to the lung, and lower expression of NCKAP5 in patient tumors was significantly associated with worse overall survival. NCKAP5 may be important for initiation or progression of non-small cell lung cancer in humans.


2020 ◽  
Author(s):  
Shahan Mamoor

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that tensin 1, encoded by TNS1, was among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. TNS1 expression was significantly decreased in NSCLC tumors as compared to the lung, and lower expression of TNS1 in patient tumors was significantly associated with worse overall survival. TNS1 may be important for initiation or progression of non-small cell lung cancer in humans.


2020 ◽  
Author(s):  
Shahan Mamoor

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding the thymyocyte selection-associated high mobility box protein family member 2 transcription factor Tox2 was among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. Tox2 expression was significantly decreased in NSCLC tumors as compared to the lung, and lower expression of Tox2 in patient tumors was significantly associated with worse overall survival. Tox2 may be important for initiation or progression of non-small cell lung cancer in humans.


2020 ◽  
Author(s):  
Shahan Mamoor

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that ROBO4 was among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. ROBO4 expression was significantly decreased in NSCLC tumors as compared to the lung, and lower expression of ROBO4 in patient tumors was significantly associated with worse overall survival. ROBO4 may be important for initiation or progression of non-small cell lung cancer in humans.


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