The roundabout guidance receptor 4, ROBO4, is differentially expressed in non-small cell lung cancer and associates with patient survival.
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Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that ROBO4 was among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. ROBO4 expression was significantly decreased in NSCLC tumors as compared to the lung, and lower expression of ROBO4 in patient tumors was significantly associated with worse overall survival. ROBO4 may be important for initiation or progression of non-small cell lung cancer in humans.
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2020 ◽
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