scholarly journals Over-expression of desumoylating isopeptidase 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified desumoylating isopeptidase 1, encoded by DESI1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. DESI1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of DESI1 was correlated with recurrence-free survival in black patients with high mutational burden. DESI1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of MLX, MAX dimerization protein in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified MLX, MAX dimerization protein, encoded by MLX, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. MLX was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of MLX was correlated with recurrence-free survival in black patients with low mutational burden. MLX may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of pyrophosphatase (inorganic) 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified pyrophosphatase (inorganic) 1, encoded by PPA1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PPA1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of PPA1 was correlated with recurrence-free survival in black patients with low mutational burden. PPA1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of tubulin gamma 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified tubulin gamma 1, encoded by TUBG1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. TUBG1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of TUBG1 was correlated with recurrence-free survival in white patients with low mutational burden, and in black patients with high mutational burden. TUBG1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of cytoskeleton associated protein 2 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified cytoskeleton associated protein 2, encoded by CKAP2, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CKAP2 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of CKAP2 was correlated with recurrence-free survival in white patients with high and low mutational burden. CKAP2 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of diazepam binding inhibitor, acyl-CoA binding protein in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Binding Protein ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified diazepam binding inhibitor, acyl-CoA binding protein, encoded by DBI, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. DBI was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of DBI was correlated with recurrence-free survival in black patients with low mutational burden. DBI may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of dihydrolipoamide S-acetyltransferase in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified dihydrolipoamide S-acetyltransferase, encoded by DLAT, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. DLAT was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of DLAT was correlated with overall survival in black patients with low mutational burden. DLAT may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of mitochondrial phosphoenolpyruvate carboxykinase 2 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified phosphoenolpyruvate carboxykinase 2, mitochondrial, encoded by PCK2, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PCK2 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of PCK2 was correlated with recurrence-free survival in black patients with high mutational burden. PCK2 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of centromere protein U in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Centromere Protein ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified centromere protein U, encoded by CENPU, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CENPU was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of CENPU was correlated with recurrence-free survival in white patients with low mutational burden. CENPU may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of propionyl-CoA carboxylase beta subunit in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Beta Subunit ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified propionyl-CoA carboxylase beta subunit, encoded by PCCB, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PCCB was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of PCCB was correlated with recurrence-free survival in white patients with low mutational burden. PCCB may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of non-SMC condensin I complex subunit G in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified non-SMC condensin I complex subunit G, encoded by NCAPG, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. NCAPG was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of NCAPG was correlated with recurrence-free survival in white patients with low mutational burden. NCAPG may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

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