ASNSD1 is differentially expressed in brain metastatic human breast cancer.

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Asparagine Synthetase ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that asparagine synthetase domain containing 1, encoded by ASNSD1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ASNSD1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of ASNSD1 in primary tumors was significantly correlated with patient post-progression survival. Modulation of ASNSD1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

Palladin is differentially expressed in both lymph node and brain metastases in human breast cancer.

10.31219/osf.io/24u98 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Brain Metastases ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that palladin, encoded by PALLD, was among the genes whose expression was most quantitatively different in the brain metastases of patients with metastatic breast cancer. PALLD mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of PALLD in primary tumors was significantly correlated with patient overall survival in patients with breast cancer. Modulation of PALLD expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain.

GRHL3 is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/qpnhj ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that grainyhead-like transcription factor 3, encoded by GRHL3, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. GRHL3 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of GRHL3 in primary tumors was significantly correlated with patient overall survival. Modulation of GRHL3 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

RSU1 is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/wsjdc ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that ras suppressor protein 1, encoded by RSU1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. RSU1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of RSU1 in primary tumors was correlated with patient overall survival. Modulation of RSU1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

RIPPLY2 is differentially expressed in brain metastatic human breast cancer.

10.31219/osf.io/wztqd ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Free Survival ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that ripply transcriptional repressor 2, encoded by RIPPLY2, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. RIPPLY2 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of RIPPLY2 in primary tumors was significantly correlated with patient recurrence-free survival. Modulation of RIPPLY2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

TUBE1 is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/gef7s ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that tubulin epsilon 1, encoded by TUBE1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. TUBE1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of TUBE1 in primary tumors was significantly correlated with patient overall survival. Modulation of TUBE1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

ADPGK is differentially expressed in brain metastatic human breast cancer.

10.31219/osf.io/65x4c ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Microarray Data ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that the ADP-dependent glucokinase, encoded by ADPGK, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ADPGK mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of ADPGK in primary tumors was significantly correlated with patient overall survival. Modulation of ADPGK expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

DR1 is differentially expressed in brain metastatic human breast cancer.

10.31219/osf.io/7yxj2 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Microarray Data ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that the down-regulator of transcription 1, TBP-binding (negative cofactor 2), encoded by DR1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. DR1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of DR1 in primary tumors was significantly correlated with patient post-progression survival. Modulation of DR1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

KRIT1 is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/q4dw5 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that the Krev Interaction Trapped Protein 1 (KRIT1), ankyrin repeat containing, encoded by KRIT1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. KRIT1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of KRIT1 in primary tumors was significantly correlated with patient overall survival. Modulation of KRIT1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

ABI3BP is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/b4mgz ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that ABI family member 3 binding protein, encoded by ABI3BP, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ABI3BP mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of ABI3BP in primary tumors was correlated with patient overall survival. Modulation of ABI3BP expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

PRKAG2 is differentially expressed in brain metastatic human breast cancer.

10.31219/osf.io/wm5nd ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Amp Activated Protein Kinase ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that 5'-AMP-activated protein kinase subunit gamma-2 , encoded by PRKAG2, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. PRKAG2 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of PRKAG2 in primary tumors was significantly correlated with patient overall survival. Modulation of PRKAG2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.