Differential expression of protein regulator of cytokinesis 1 in cancers of the breast.

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the protein regulator of cytokinesis 1, PRC1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PRC1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. PRC1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PRC1 in primary tumors of the breast was correlated with overall survival in patients with basal, luminal A, and luminal B subtype cancer, but in a contrary manner. PRC1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of MMP11 in cancers of the breast.

10.31219/osf.io/3krf4 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the matrix metallopeptidase 11, MMP11, when comparing primary tumors of the breast to the tissue of origin, the normal breast. MMP11 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. MMP11 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of MMP11 in primary tumors of the breast was correlated with overall survival in patients with luminal A and luminal B subtype cancer, but in a contrary manner. MMP11 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of CKS2 in cancers of the breast.

10.31219/osf.io/zdhr3 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Regulatory Subunit ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the CDC28 protein kinase regulatory subunit 2, CKS2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CKS2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. CKS2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CKS2 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. CKS2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of TUFT1 in cancers of the breast.

10.31219/osf.io/3rk7f ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the tuftelin 1, TUFT1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TUFT1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. TUFT1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TUFT1 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with basal and luminal A subtype cancer. TUFT1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of KIF11 in cancers of the breast.

10.31219/osf.io/xh2ng ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the kinesin family member 11, KIF11, when comparing primary tumors of the breast to the tissue of origin, the normal breast. KIF11 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. KIF11 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of KIF11 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. KIF11 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of hematological and neurological expressed 1 in cancers of the breast.

10.31219/osf.io/y9xjm ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the hematological and neurological expressed 1, HN1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. HN1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. HN1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of HN1 in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer. HN1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of ANLN in cancers of the breast.

10.31219/osf.io/57eg2 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Actin Binding ◽

Luminal A ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the anillin actin binding protein, ANLN, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ANLN was also differentially expressed in the tumor cells of patients with triple negative breast cancer. ANLN mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ANLN in primary tumors of the breast was correlated with overall survival in patients with luminal A and luminal B subtype cancers. ANLN may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of NACC1 in cancers of the breast.

10.31219/osf.io/gbk9w ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Gene Encoding ◽

Primary Tumors ◽

Luminal B ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding nucleus accumbens associated 1, NACC1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. NACC1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. NACC1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of NACC1 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with luminal B subtype cancer. NACC1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of GINS1 in cancers of the breast.

10.31219/osf.io/xu4cs ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the GINS complex subunit 1, GINS1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. GINS1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. GINS1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of GINS1 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. GINS1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of CASC5 in cancers of the breast.

10.31219/osf.io/jhkq8 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Cancer Susceptibility ◽

Normal Breast ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding cancer susceptibility candidate 5, CASC5, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CASC5 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. CASC5 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CASC5 in primary tumors of the breast was correlated with overall survival in patients with luminal B subtype cancer. CASC5 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of BUB1B in cancers of the breast.

10.31219/osf.io/y6m29 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Mitotic Checkpoint ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the BUB1 mitotic checkpoint serine/threonine kinase B, BUB1B, when comparing primary tumors of the breast to the tissue of origin, the normal breast. BUB1B was also differentially expressed in the tumor cells of patients with triple negative breast cancer. BUB1B mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of BUB1B in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. BUB1B may be of relevance to initiation, maintenance or progression of cancers of the female breast.