HHATL is differentially expressed in primary tumors and brain metastases in humans with breast cancer.
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We report here the differential expression of the hedgehog acyltransferase-like, encoded by HHATL, in the primary tumors and brain metastases of humans with breast cancer. HHATL mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. These data combined suggest that down-regulation of HHATL is a conserved event, both during transformation of breast tissues and progression to central nervous system metastasis and further point to potential importance of modulation of HHATL during progression of human breast cancer.