scholarly journals Molecular genetic mechanisms, human sex determination levels and disorders of sexual differentiation

2019 ◽  
Vol 23 (4) ◽  
pp. 717-722
Author(s):  
T.I. Shevchuk ◽  
S.S. Khliestova ◽  
S.M. Horbatiuk ◽  
T.B. Vasenko ◽  
O.V. Sprut
Keyword(s):  
Sex Determination ◽  
Sexual Differentiation ◽  
Functional Integration ◽  
Molecular Genetic ◽  
Individual Development ◽  
Genetic Determinants ◽  
Multi Stage ◽  
Genetic Mechanisms ◽  
Stage Process ◽  
Disorders Of Sexual Differentiation

Annotation. The purpose of this work — an analysis and a summary of results of scientific research on problems of molecular genetic mechanisms and human sex determination levels. Literature analysis was performed in scientometric databases of Google Scholar, MedLine, Web of Science, Scopus for 2014–2018. Sex determination is a complex multi-stage process secured by functional integration of genetic determinants, products thereof, and the conditions of individual development for its realization. Sexual differentiation occurs at genetic, gonadal, hormonal, somatic, psychological and social levels, and disorders at any of them may lead to deviations from normal sex determination.

Her, a gene required for sexual differentiation in Drosophila, encodes a zinc finger protein with characteristics of ZFY-like proteins and is expressed independently of the sex determination hierarchy

Development ◽  
1998 ◽  
Vol 125 (2) ◽  
pp. 225-235
Author(s):  
H. Li ◽  
B.S. Baker
Keyword(s):  
Sex Determination ◽  
Sexual Differentiation ◽  
Zinc Finger Protein ◽  
Genetic Characterization ◽  
Zinc Fingers ◽  
Molecular Genetic ◽  
Control Female ◽  
Finger Protein ◽  
Molecular Genetic Characterization

The zygotic function of the hermaphrodite (her) gene of Drosophila plays an important role in sexual differentiation. Our molecular genetic characterization of her suggests that her is expressed sex non-specifically and independently of other known sex determination genes and that it acts together with the last genes in the sex determination hierarchy, doublesex and intersex, to control female sexual differentiation. Consistent with such a terminal function in sexual differentiation, her encodes a protein with C2H2-type zinc fingers. The her zinc fingers are atypical and similar to the even-numbered zinc fingers of ZFY and ZFX proteins in humans and other vertebrates.

Disorders of Sexual Differentiation: New Epigenetic Insights of Hypospadia.

2010 ◽  
pp. P1-317-P1-317
Author(s):  
A. Vottero ◽  
I. Viani ◽  
R. Minari ◽  
V. Gasco ◽  
S. Bernasconi ◽  
...  
Keyword(s):  
Sexual Differentiation ◽  
Disorders Of Sexual Differentiation
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