Her, a gene required for sexual differentiation in Drosophila, encodes a zinc finger protein with characteristics of ZFY-like proteins and is expressed independently of the sex determination hierarchy

Development ◽  
1998 ◽  
Vol 125 (2) ◽  
pp. 225-235
Author(s):  
H. Li ◽  
B.S. Baker
Keyword(s):  
Sex Determination ◽  
Sexual Differentiation ◽  
Zinc Finger Protein ◽  
Genetic Characterization ◽  
Zinc Fingers ◽  
Molecular Genetic ◽  
Control Female ◽  
Finger Protein ◽  
Molecular Genetic Characterization

The zygotic function of the hermaphrodite (her) gene of Drosophila plays an important role in sexual differentiation. Our molecular genetic characterization of her suggests that her is expressed sex non-specifically and independently of other known sex determination genes and that it acts together with the last genes in the sex determination hierarchy, doublesex and intersex, to control female sexual differentiation. Consistent with such a terminal function in sexual differentiation, her encodes a protein with C2H2-type zinc fingers. The her zinc fingers are atypical and similar to the even-numbered zinc fingers of ZFY and ZFX proteins in humans and other vertebrates.

scholarly journals Metabolic Flux in Both the Purine Mononucleotide and Histidine Biosynthetic Pathways Can Influence Synthesis of the Hydroxymethyl Pyrimidine Moiety of Thiamine in Salmonella enterica

2002 ◽  
Vol 184 (22) ◽  
pp. 6130-6137 ◽  
Author(s):  
Shara Allen ◽  
Julie L. Zilles ◽  
Diana M. Downs
Keyword(s):  
Metabolic Flux ◽  
Genetic Characterization ◽  
Molecular Genetic ◽  
Thiamine Pyrophosphate ◽  
Wild Type ◽  
Regulatory Pathway ◽  
Informational Suppressors ◽  
Pyrimidine Moiety ◽  
Molecular Genetic Characterization

ABSTRACT Together, the biosyntheses of histidine, purines, and thiamine pyrophosphate (TPP) contain examples of convergent, divergent, and regulatory pathway integration. Mutations in two purine biosynthetic genes (purI and purH) affect TPP biosynthesis due to flux through the purine and histidine pathways. The molecular genetic characterization of purI mutants and their respective pseudorevertants resulted in the conclusion that <1% of the wild-type activity of the PurI enzyme was sufficient for thiamine but not for purine synthesis. The respective pseudorevertants were found to be informational suppressors. In addition, it was shown that accumulation of the purine intermediate aminoimidazole carboxamide ribotide inhibits thiamine synthesis, specifically affecting the conversion of aminoimidazole ribotide to hydroxymethyl pyrimidine.

Molecular genetic characterization of rabies virus glycoprotein gene sequences from rabid dogs in Bangkok and neighboring provinces in Thailand, 2013–2014

2016 ◽  
Vol 161 (5) ◽  
pp. 1261-1271 ◽  
Author(s):  
Surachet Benjathummarak ◽  
Chanon Fa-ngoen ◽  
Chonlatip Pipattanaboon ◽  
Khwanchit Boonha ◽  
Pongrama Ramasoota ◽  
...  
Keyword(s):  
Rabies Virus ◽  
Genetic Characterization ◽  
Molecular Genetic ◽  
Gene Sequences ◽  
Rabies Virus Glycoprotein ◽  
Virus Glycoprotein ◽  
Glycoprotein Gene ◽  
Molecular Genetic Characterization

Molecular genetic characterization of the Lr34/Yr18 slow rusting resistance gene region in wheat

2006 ◽  
Vol 114 (1) ◽  
pp. 21-30 ◽  
Author(s):  
E. S. Lagudah ◽  
H. McFadden ◽  
R. P. Singh ◽  
J. Huerta-Espino ◽  
H. S. Bariana ◽  
...  
Keyword(s):  
Resistance Gene ◽  
Genetic Characterization ◽  
Molecular Genetic ◽  
Gene Region ◽  
Slow Rusting ◽  
Molecular Genetic Characterization

Molecular Genetic Characterization of Two Insular Asian Cat Species, Bornean Bay Cat and Iriomote Cat

1999 ◽  
pp. 223-248 ◽  
Author(s):  
Warren E. Johnson ◽  
Fumiharu Shinyashiki ◽  
Marilyn Menotti Raymond ◽  
Carlos Driscoll ◽  
Charles Leh ◽  
...  
Keyword(s):  
Genetic Characterization ◽  
Molecular Genetic ◽  
Molecular Genetic Characterization

scholarly journals Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2

Haematologica ◽  
2018 ◽  
Vol 103 (8) ◽  
pp. e348-e350 ◽  
Author(s):  
Constance Baer ◽  
Verena Muehlbacher ◽  
Wolfgang Kern ◽  
Claudia Haferlach ◽  
Torsten Haferlach
Keyword(s):  
Genetic Characterization ◽  
Molecular Genetic ◽  
Lymphoid Neoplasms ◽  
Molecular Genetic Characterization
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