scholarly journals Twenty-year follow-up of protective immunity of the Oka strain of live varicella vaccine recipients with childhood nephrotic syndrome

1994 ◽  
Vol 7 (2) ◽  
pp. 213-216
Author(s):  
Shigeru Minowa ◽  
Sachiko Takeichi ◽  
Yoshizo Asano ◽  
Takehiko Yasaki ◽  
Kazuo Tsuzuki ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Protective Immunity ◽  
Varicella Vaccine ◽  
Childhood Nephrotic Syndrome

Experience and Reason: Twenty-Year Follow-Up of Protective Immunity of the Oka Strain Live Varicella Vaccine

PEDIATRICS ◽  
1994 ◽  
Vol 94 (4) ◽  
pp. 524-526
Author(s):  
Yoshizo Asano ◽  
Sadao Suga ◽  
Tetsushi Yoshikawa ◽  
Ikuko Kobayashi ◽  
Takehiko Yazaki ◽  
...  
Keyword(s):  
United States ◽  
Clinical Trials ◽  
Protective Immunity ◽  
Protective Efficacy ◽  
Varicella Vaccine ◽  
The United States ◽  
Follow Up Study ◽  
Waning Immunity

Since the first report on the development of a live attenuated varicella vaccine in 1974, the vaccine has been studied extensively, with largely favorable results, in both healthy and leukemic children. It is now licensed in Japan, Korea, and some European countries, and is being considered for licensure in the United States. Although various clinical trials have established the safety, immunogenicity, and the efficacy of the vaccine, concern has been expressed that waning immunity in the vaccine recipients might allow the occurrence of more severe varicella later in life. We show data relevant to this concern on the approximately 20-year follow-up study of the vaccine recipients; this work further extends the experience of a long-term protective efficacy of the vaccine.

scholarly journals Steroid treatment for the first episode of childhood nephrotic syndrome: comparison of the 8 and 12 weeks regimen using an individual patient data meta-analysis

2021 ◽  
Author(s):  
Anne M. Schijvens ◽  
Nynke Teeninga ◽  
Eiske M. Dorresteijn ◽  
Steven Teerenstra ◽  
Nicholas J. Webb ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Steroid Treatment ◽  
First Episode ◽  
Childhood Nephrotic Syndrome ◽  
Steroid Sensitive Nephrotic Syndrome ◽  
Steroid Sensitive ◽  
First Relapse ◽  
Steroid Regimen

AbstractSteroids are the cornerstone of the treatment of childhood nephrotic syndrome. The optimal duration for the first episode remains a matter of debate. The aim of this study is to determine whether the 8 weeks International Study of Kidney Disease in Children (ISKDC) regimen is equally effective as the 12 weeks steroid regimen from the German society of pediatric nephrology (Arbeitsgemeinschaft für Pädiatrische Nephrologie [APN]). An individual patient data (IPD) meta-analysis of randomized controlled trials reporting on prednisolone treatment for a first episode of childhood nephrotic syndrome was conducted. European trials aimed at investigating the ISKDC and/or APN steroid regimen were selected. The lead investigators of the selected trials were requested to provide the IPD of the specific treatment groups. Four trials included European cohorts using dosing schedules according to the regimens studied. IPD of two trials were available. A significant difference was found in time to first relapse after cessation of steroid treatment between the 8 and 12 weeks treatment group with a median time to relapse of 29 and 63 days, respectively. Moreover, relapse rate ratios during total follow-up were 51% higher for the 8 weeks regimen. Finally, younger children have a significantly lower time to first relapse and frequently relapsing nephrotic syndrome.Conclusions: The results of this IPD meta-analysis suggest that the 8 weeks steroid regimen for a first episode of steroid-sensitive nephrotic syndrome may not be equally effective as the 12 weeks steroid regimen. Moreover, this study highlights the importance of using uniform definitions to enable accurate comparison and interpretation of trial results.Trial registration: Registration number: CRD42020199244, date of registration 16-08-2020 What is Known:• Steroids are the cornerstone of the treatment of childhood nephrotic syndrome, however the optimal duration for the first episode remains a matter of debate.• Currently, the 8 weeks ISKDC protocol and 12 weeks APN protocol are among the most frequently used protocols in Europe. What is New:• The 8 weeks steroid regimen for a first episode of steroid-sensitive nephrotic syndrome may not be equally effective as the 12 weeks steroid regimen for the treatment of a first episode of nephrotic syndrome.• Younger children have a significantly shorter time to first relapse and time to frequent relapsing nephrotic syndrome.

scholarly journals Management of idiopathic childhood nephrotic syndrome in sub-Saharan Africa: Ibadan consensus statement

2021 ◽  
Vol 99 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Christopher Esezobor ◽  
Adebowale D. Ademola ◽  
Adewale E. Adetunji ◽  
Emmanuel A. Anigilaje ◽  
Anthony Batte ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Consensus Statement ◽  
Sub Saharan Africa ◽  
Childhood Nephrotic Syndrome ◽  
Sub Saharan

Haemostatic measurements in childhood nephrotic syndrome

1991 ◽  
Vol 150 (5) ◽  
pp. 374-378 ◽  
Author(s):  
A. T. H. Elidrissy ◽  
M. B. Abdurrahman ◽  
H. M. Bahakim ◽  
M. D. Jones ◽  
A. M. A. Gader
Keyword(s):  
Nephrotic Syndrome ◽  
Childhood Nephrotic Syndrome
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