In vitro Transformation of Hamster Kidney Cells by Human Adenovirus Type 12.

1964 ◽  
Vol 115 (4) ◽  
pp. 870-874 ◽  
Author(s):  
W. D. McBride ◽  
A. Wiener
Keyword(s):  
Human Adenovirus ◽  
Adenovirus Type ◽  
Kidney Cells ◽  
In Vitro Transformation ◽  
Human Adenovirus Type 12

scholarly journals IN VITRO TRANSFORMATION BY THE ADENOVIRUS-SV40 HYBRID VIRUSES

1967 ◽  
Vol 125 (4) ◽  
pp. 647-656 ◽  
Author(s):  
H. J. Igel ◽  
P. H. Black
Keyword(s):  
Tumor Cells ◽  
Target Cell ◽  
Adenovirus Type ◽  
Transformed Cells ◽  
Kidney Cells ◽  
Viral Genomes ◽  
In Vitro Transformation

Tumors induced with hamster kidney cells transformed by the adeno 2-, adeno 3-, adeno 7-, and adeno 12-SV40 hybrid viruses, and by adenovirus type 12, were examined histologically. The tumors induced with adeno 2-, adeno 3-, and adeno 7-SV40-transformed cells were similar to tumors induced with SV40-transformed hamster kidney cells but contained cells intermediate in morphology between SV40 and adenovirus tumor cells and occasionally contained nests of adenovirus-like cells. Cells transformed by the adeno 12-SV40 hybrid and by adenovirus type 12 gave rise to morphologically similar tumors. The results suggest that both viral genomes are operative in hybrid-transformed cells but that one genome is apparently responsible for the predominant morphology of the tumor. Evidence that the morphology of a single transformed target cell is determined by the transforming genome was discussed.

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