Upper extremity function and its relation with hand sensation and upper extremity strength in patients with multiple sclerosis

2012 ◽  
Vol 30 (4) ◽  
pp. 369-374 ◽  
Author(s):  
Arzu Guclu-Gunduz ◽  
Seyit Citaker ◽  
Bijen Nazliel ◽  
Ceyla Irkec
Keyword(s):  
Multiple Sclerosis ◽  
Upper Extremity ◽  
Extremity Function ◽  
Upper Extremity Function

Assessment of Upper Extremity Function in Multiple Sclerosis: Review and Opinion

2014 ◽  
Vol 126 (5) ◽  
pp. 102-108 ◽  
Author(s):  
George H. Kraft ◽  
Dagmar Amtmann ◽  
Susan E. Bennett ◽  
Marcia Finlayson ◽  
Matthew H. Sutliff ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Upper Extremity ◽  
Extremity Function ◽  
Upper Extremity Function

scholarly journals A smartphone sensor-based digital outcome assessment of multiple sclerosis

2021 ◽  
pp. 135245852110285
Author(s):  
Xavier Montalban ◽  
Jennifer Graves ◽  
Luciana Midaglia ◽  
Patricia Mulero ◽  
Laura Julian ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Upper Extremity ◽  
Clinical Care ◽  
Intraclass Correlation ◽  
Rank Correlation ◽  
Static Balance ◽  
Balance Test ◽  
Passive Monitoring ◽  
Extremity Function ◽  
Upper Extremity Function

Background: Sensor-based monitoring tools fill a critical gap in multiple sclerosis (MS) research and clinical care. Objective: The aim of this study is to assess performance characteristics of the Floodlight Proof-of-Concept (PoC) app. Methods: In a 24-week study (clinicaltrials.gov: NCT02952911), smartphone-based active tests and passive monitoring assessed cognition (electronic Symbol Digit Modalities Test), upper extremity function (Pinching Test, Draw a Shape Test), and gait and balance (Static Balance Test, U-Turn Test, Walk Test, Passive Monitoring). Intraclass correlation coefficients (ICCs) and age- or sex-adjusted Spearman’s rank correlation determined test–retest reliability and correlations with clinical and magnetic resonance imaging (MRI) outcome measures, respectively. Results: Seventy-six people with MS (PwMS) and 25 healthy controls were enrolled. In PwMS, ICCs were moderate-to-good (ICC(2,1) = 0.61–0.85) across tests. Correlations with domain-specific standard clinical disability measures were significant for all tests in the cognitive ( r = 0.82, p < 0.001), upper extremity function (|r|= 0.40–0.64, all p < 0.001), and gait and balance domains ( r = −0.25 to −0.52, all p < 0.05; except for Static Balance Test: r = −0.20, p > 0.05). Most tests also correlated with Expanded Disability Status Scale, 29-item Multiple Sclerosis Impact Scale items or subscales, and/or normalized brain volume. Conclusion: The Floodlight PoC app captures reliable and clinically relevant measures of functional impairment in MS, supporting its potential use in clinical research and practice.

scholarly journals Smartphone-based remote assessment of upper extremity function for multiple sclerosis using the Draw a Shape Test

2020 ◽  
Vol 41 (5) ◽  
pp. 054002 ◽  
Author(s):  
A P Creagh ◽  
C Simillion ◽  
A Scotland ◽  
F Lipsmeier ◽  
C Bernasconi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Upper Extremity ◽  
Extremity Function ◽  
Remote Assessment ◽  
Upper Extremity Function

scholarly journals Personalised inpatient multidisciplinary rehabilitation elicits clinically relevant improvements in physical function in patients with multiple sclerosis – The Danish MS Hospitals Rehabilitation Study

2021 ◽  
Vol 7 (1) ◽  
pp. 205521732198938
Author(s):  
Lars G Hvid ◽  
Tobias Gaemelke ◽  
Ulrik Dalgas ◽  
Mette K Slipsager ◽  
Peter V Rasmussen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Physical Function ◽  
Upper Extremity ◽  
Step Test ◽  
Multidisciplinary Rehabilitation ◽  
Extremity Function ◽  
Walking Capacity ◽  
Upper Extremity Function ◽  
Dynamic Gait Index

Purpose Evidence of the effects of inpatient multidisciplinary rehabilitation (MDR) on physical function in patients with multiple sclerosis (MS) is limited, particularly whether clinically relevant improvements can be achieved. The aim of this study, therefore, was to investigate the effects of personalised inpatient MDR on the physical function of MS patients. Methods Embedded in the Danish MS Hospitals Rehabilitation Study, a pragmatic study was performed in MS patients undergoing four weeks of inpatient MDR specifically targeting physical function. Outcomes were assessed at baseline (n = 142), at discharge (n = 137) and at six months follow-up (n = 126) using the six-minute walk test (6MWT), six-spot step test (SSST), five times sit to stand test (5STS), nine-hole peg test (NHPT), dynamic gait index (DGI) and 12-item MS walking scale (MSWS). Results From Baseline-to-Discharge, significant and clinically relevant improvements were found in all measures of walking capacity (6MWT, SSST, 5STS, DGI and MSWS; p < 0.05) along with significant (but not clinically relevant) improvements in upper extremity function (NHPT; p < 0.05). Whilst comparable improvements were observed within subgroups of MS phenotype (relapsing-remitting [RR] vs. secondary + primary progressive [SP + PP]), disease severity (moderate [EDSS2.5–5.5] vs. severe [EDSS6.0–7.5]) and age (young/middle-aged [Age24–59] vs. old [Age60–65]), an attenuated adaptation was nevertheless observed for 6MWT in the most affected and vulnerable subgroups (i.e. SP + PP, EDSS6.0–7.5 and Age60–65). The significant improvements in walking capacity and upper extremity function persisted at six months follow-up but did not exceed anymore the thresholds regarded as clinically relevant. Conclusion The results provide novel evidence that personalised inpatient MDR targeting physical function in MS patients elicits significant and clinically relevant improvements in physical function.

scholarly journals Tasks of activities of daily living (ADL) are more valuable than the classical neurological examination to assess upper extremity function and mobility in multiple sclerosis

2018 ◽  
Vol 25 (12) ◽  
pp. 1673-1681 ◽  
Author(s):  
Caspar EP van Munster ◽  
Marcus D’Souza ◽  
Saskia Steinheimer ◽  
Christian P Kamm ◽  
Jessica Burggraaff ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Activities Of Daily Living ◽  
Upper Extremity ◽  
Neurological Examination ◽  
Daily Living ◽  
Motor Dysfunction ◽  
Linear Regression Models ◽  
Extremity Function ◽  
Upper Extremity Function ◽  
Nine Hole Peg Test

Background: Accurate clinical assessment in multiple sclerosis (MS) is challenging. The Assess MS system is being developed to automatically quantify motor dysfunction in MS, including upper extremity function (UEF) and mobility. Objective: To determine to what extent combinations of standardized movements included in the Assess MS system explain accepted measures of UEF and mobility. Methods: MS patients were recruited at four European MS centres. Eight movements were selected, including tasks of activities of daily living (ADL) and classical neurological tests. Movements were recorded on video and rated by experienced neurologists ( n = 5). Subsequently, multivariate linear regression models were performed to explain the variance of the Nine-Hole Peg Test (9HPT), Arm Function in Multiple Sclerosis Questionnaire (AMSQ) and Timed-25 Foot Walk test (T25WT). Results: In total, 257 patients were included. The movements explained 62.9% to 80.1% of the variance of the 9HPT models, 43.3% and 44.3% of the AMSQ models and 70.8% of the T25WT. In all models, tasks of ADL contributed most to the variance. Conclusion: Combinations of movements are valuable to assess UEF and mobility. Incorporating ADL tasks into daily clinical practice and clinical trials may be more valuable than the classical neurological examination of UEF and mobility.

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