scholarly journals A smartphone sensor-based digital outcome assessment of multiple sclerosis

2021 ◽  
pp. 135245852110285
Author(s):  
Xavier Montalban ◽  
Jennifer Graves ◽  
Luciana Midaglia ◽  
Patricia Mulero ◽  
Laura Julian ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Upper Extremity ◽  
Clinical Care ◽  
Intraclass Correlation ◽  
Rank Correlation ◽  
Static Balance ◽  
Balance Test ◽  
Passive Monitoring ◽  
Extremity Function ◽  
Upper Extremity Function

Background: Sensor-based monitoring tools fill a critical gap in multiple sclerosis (MS) research and clinical care. Objective: The aim of this study is to assess performance characteristics of the Floodlight Proof-of-Concept (PoC) app. Methods: In a 24-week study (clinicaltrials.gov: NCT02952911), smartphone-based active tests and passive monitoring assessed cognition (electronic Symbol Digit Modalities Test), upper extremity function (Pinching Test, Draw a Shape Test), and gait and balance (Static Balance Test, U-Turn Test, Walk Test, Passive Monitoring). Intraclass correlation coefficients (ICCs) and age- or sex-adjusted Spearman’s rank correlation determined test–retest reliability and correlations with clinical and magnetic resonance imaging (MRI) outcome measures, respectively. Results: Seventy-six people with MS (PwMS) and 25 healthy controls were enrolled. In PwMS, ICCs were moderate-to-good (ICC(2,1) = 0.61–0.85) across tests. Correlations with domain-specific standard clinical disability measures were significant for all tests in the cognitive ( r = 0.82, p < 0.001), upper extremity function (|r|= 0.40–0.64, all p < 0.001), and gait and balance domains ( r = −0.25 to −0.52, all p < 0.05; except for Static Balance Test: r = −0.20, p > 0.05). Most tests also correlated with Expanded Disability Status Scale, 29-item Multiple Sclerosis Impact Scale items or subscales, and/or normalized brain volume. Conclusion: The Floodlight PoC app captures reliable and clinically relevant measures of functional impairment in MS, supporting its potential use in clinical research and practice.

Assessment of Upper Extremity Function in Multiple Sclerosis: Review and Opinion

2014 ◽  
Vol 126 (5) ◽  
pp. 102-108 ◽  
Author(s):  
George H. Kraft ◽  
Dagmar Amtmann ◽  
Susan E. Bennett ◽  
Marcia Finlayson ◽  
Matthew H. Sutliff ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Upper Extremity ◽  
Extremity Function ◽  
Upper Extremity Function

scholarly journals Smartphone-based remote assessment of upper extremity function for multiple sclerosis using the Draw a Shape Test

2020 ◽  
Vol 41 (5) ◽  
pp. 054002 ◽  
Author(s):  
A P Creagh ◽  
C Simillion ◽  
A Scotland ◽  
F Lipsmeier ◽  
C Bernasconi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Upper Extremity ◽  
Extremity Function ◽  
Remote Assessment ◽  
Upper Extremity Function

scholarly journals Personalised inpatient multidisciplinary rehabilitation elicits clinically relevant improvements in physical function in patients with multiple sclerosis – The Danish MS Hospitals Rehabilitation Study

2021 ◽  
Vol 7 (1) ◽  
pp. 205521732198938
Author(s):  
Lars G Hvid ◽  
Tobias Gaemelke ◽  
Ulrik Dalgas ◽  
Mette K Slipsager ◽  
Peter V Rasmussen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Physical Function ◽  
Upper Extremity ◽  
Step Test ◽  
Multidisciplinary Rehabilitation ◽  
Extremity Function ◽  
Walking Capacity ◽  
Upper Extremity Function ◽  
Dynamic Gait Index

Purpose Evidence of the effects of inpatient multidisciplinary rehabilitation (MDR) on physical function in patients with multiple sclerosis (MS) is limited, particularly whether clinically relevant improvements can be achieved. The aim of this study, therefore, was to investigate the effects of personalised inpatient MDR on the physical function of MS patients. Methods Embedded in the Danish MS Hospitals Rehabilitation Study, a pragmatic study was performed in MS patients undergoing four weeks of inpatient MDR specifically targeting physical function. Outcomes were assessed at baseline (n = 142), at discharge (n = 137) and at six months follow-up (n = 126) using the six-minute walk test (6MWT), six-spot step test (SSST), five times sit to stand test (5STS), nine-hole peg test (NHPT), dynamic gait index (DGI) and 12-item MS walking scale (MSWS). Results From Baseline-to-Discharge, significant and clinically relevant improvements were found in all measures of walking capacity (6MWT, SSST, 5STS, DGI and MSWS; p < 0.05) along with significant (but not clinically relevant) improvements in upper extremity function (NHPT; p < 0.05). Whilst comparable improvements were observed within subgroups of MS phenotype (relapsing-remitting [RR] vs. secondary + primary progressive [SP + PP]), disease severity (moderate [EDSS2.5–5.5] vs. severe [EDSS6.0–7.5]) and age (young/middle-aged [Age24–59] vs. old [Age60–65]), an attenuated adaptation was nevertheless observed for 6MWT in the most affected and vulnerable subgroups (i.e. SP + PP, EDSS6.0–7.5 and Age60–65). The significant improvements in walking capacity and upper extremity function persisted at six months follow-up but did not exceed anymore the thresholds regarded as clinically relevant. Conclusion The results provide novel evidence that personalised inpatient MDR targeting physical function in MS patients elicits significant and clinically relevant improvements in physical function.

Development and Reliability of an Upper Extremity Function Test for the Elderly: The TEMPA

1993 ◽  
Vol 60 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Johanne Desrosiers ◽  
Réjean Hébert ◽  
Elisabeth Dutil ◽  
Gina Bravo
Keyword(s):  
Upper Extremity ◽  
Intraclass Correlation ◽  
Temporal Stability ◽  
Correlation Coefficients ◽  
The Elderly ◽  
Critical Element ◽  
Extremity Function ◽  
Function Test ◽  
Upper Extremity Function ◽  
Impaired Person

Accurate assessment of upper extremity performance is a critical element in determinimg the potential independance of the physically impaired person. An upper extremity function test for the elderly, the TEMPA (Test Évaluant les Membres supérieurs des Personnes Âgées), was developed, involving nine tasks related to routine daily activities. Each task is measured by three sub-scores: speed of execution, functional rating and task analysis. A test-retest and interrater reliability study was conducted with a sample of 29 subjects, aged 62 to 82 years, with various upper extremity impairments and varying degrees of functional independance. Intraclass correlation coefficients ranged from moderate to high (0.70 to 1.0), demonstrating temporal stability and sound agreement between evaluators. A preliminary construct validity study was conducted by correlating score of the TEMPA with functional independance to basic personal care (Spearman's Rho = 0.74). The TEMPA is a reliable instrument that appears to fill a void in the evaluation of the elderly. More psychometric studies are required to confirm its validity.

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