Abstract
Thiamine (vitamin B1), cofactor for various multi-enzyme complexes in energy metabolism, and plays a major role in the synthesis of cholinesterases such as acetylcholinesterase (AChE); butyrylcholinesterase (BChE). Present study deals with the changes in the cholinesterases, γ-aminobutyric acid (GABA) and serotonin in mice brain following thiamine deficiency. Experimental mice (6–8 week old) were made thiamine deficient by intraperitoneal injection of pyrithiamine hydrobromide and fed with thiamine-deficient diet. Animals were divided into three groups, Group I (Control), Group II (thiamine deficient mice for 8 days), and Group III (thiamine deficient mice for 10 days). The higher serotonin level whereas significant decreases in the AChE, BChE and GABA level were recorded in treated groups as compared to control. Hence, vitamin B1 deficiency disturbs the cholinergic system and neurotransmitters levels in brain which may lead to neurodegenerative diseases.
Wernicke’s encephalopathy: An uncommon complication from hyperemesis gravidarum
