Anticonvulsant Agent

1984 ◽

Vol 61 (6) ◽

pp. 1085-1090 ◽

Cited By ~ 16

Author(s):

Kenji Kikuchi ◽

Christopher I. McCormick ◽

Edward A. Neuwelt

Keyword(s):

Brain Tumor ◽

Culture Medium ◽

Thymidine Incorporation ◽

Pokeweed Mitogen ◽

Immune Competence ◽

Lymphocyte Function ◽

Tumor Patients ◽

Content Type ◽

Anticonvulsant Agent

✓ This investigation was conducted to examine the immunosuppressive potential of phenytoin in vivo and to document a correlation between phenytoin therapy and depressed lymphocyte responsiveness to mitogens. It was thought that phenytoin, the most widely used anticonvulsant agent, may play some role in the immunosuppression seen in brain-tumor patients. The effect of phenytoin on mitogen-stimulated lymphocyte function was evaluated by tritiated (3H)-thymidine incorporation and lymphocyte nuclear size distribution. Lymphocytes from either phenytoin-treated or normal rabbits were incubated for 90 hours in culture medium in the presence of three mitogens: phytohemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM). Significant suppression of mitogen-induced activation of the lymphocytes from treated animals was demonstrated. The present studies suggest a possible connection between phenytoin therapy and altered immune competence in brain-tumor patients.

Download Full-text

Crystal structure of creatininium 5-(2,4-dinitrophenyl)-1,3-dimethylbarbiturate monohydrate: a potential anticonvulsant agent

Acta Crystallographica Section E Crystallographic Communications ◽

10.1107/s2056989016005247 ◽

2016 ◽

Vol 72 (5) ◽

pp. 620-623

Author(s):

Ponnusamy Poornima Devi ◽

Doraisamyraja Kalaivani

Keyword(s):

Crystal Structure ◽

Hydrogen Bonds ◽

Water Molecule ◽

Three Dimensional ◽

Pyrimidine Ring ◽

Membered Ring ◽

Anticonvulsant Agent ◽

The Mean ◽

Anions And Cations ◽

Molecular Salt

In the anion of the title hydrated molecular salt, C4H8N3O+·C12H9N4O7−·H2O [systematic name: 2-amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-3-ium 5-(2,4-dinitrophenyl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-olate monohydrate], the 2,4-dinitrophenyl ring is inclined to the mean plane of the pyrimidine ring [r.m.s. deviation = 0.37 Å] by 43.24 (8)°. The five-membered ring of the creatininium cation (2-amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-3-ium) is essentially planar with an r.m.s. deviation of 0.015 Å. In the crystal, the anions and cations are linkedviaN—H...O hydrogen bonds, forming sheets parallel to theabplane. The sheets are linkedviaO—H...O hydrogen bonds involving the water molecule, forming a three-dimensional framework. Within the framework, there are C—H...O hydrogen bonds present. The title molecular salt displays anticonvulsant and hypnotic activities.

Download Full-text

DOES THE ANTICONVULSANT AGENT SODIUM VALPROATE DISPLAY BEHAVIOURALLY SELECTIVE ANTI-OFFENSIVE ACTIVITY?

Journal of Pharmacy and Pharmacology ◽

10.1111/j.2042-7158.1990.tb14558.x ◽

1990 ◽

Vol 42 (S1) ◽

pp. 185P-185P ◽

Cited By ~ 1

Author(s):

M.Y. Hasan ◽

R.D.E. Sewell ◽

P.J. Nicholls

Keyword(s):

Sodium Valproate ◽

Anticonvulsant Agent

Download Full-text

The association between HLA-B*15:02 and phenytoin-induced severe cutaneous adverse reactions: a meta-analysis

Pharmacogenomics ◽

10.2217/pgs-2021-0126 ◽

2021 ◽

Author(s):

Thanh Huong Phung ◽

Khanh Ngoc Cong Duong ◽

Mac Ardy Junio Gloria ◽

Thien Khac Nguyen

Keyword(s):

Drug Reaction ◽

Adverse Reactions ◽

Meta Analysis ◽

Stevens Johnson Syndrome ◽

Random Effects Model ◽

Systemic Symptom ◽

Anticonvulsant Agent ◽

Johnson Syndrome ◽

Severe Cutaneous Adverse Reactions ◽

Cutaneous Adverse Reactions

Aim: Phenytoin (PHT) is a common anticonvulsant agent known for inducing severe cutaneous adverse reactions (SCARs). HLA-B*15:02 as a risk factor of PHT-induced SCARs was reported in numerous studies with inconsistent results. This meta-analysis aimed to establish pooling evidence of this association. Materials & methods: Pooled odds ratios (ORs) with 95% CIs were estimated using a random-effects model. Results: A total of 11 studies on 1389 patients, were included for the analyses. There was a significant association between HLA-B*15:02 and PHT-induced SCAR (pooled OR = 2.29, 95% CI: 1.25–4.19, p = 0.008). Furthermore, there was a significant association regarding Stevens–Johnson syndrome/toxic epidermal necrolysis (OR = 3.63, 95% CI: 2.15–6.13, p < 0.001) but no association regarding drug reaction with eosinophilia and systemic symptom. Conclusion: The results supported the recommendations of HLA-B*15:02 screening before treatment with PHT.

Download Full-text