scholarly journals Borderline Ovarian Epithelial Tumor

2020 ◽  
Author(s):  

1998 ◽  
Vol 39 (6) ◽  
pp. 1189
Author(s):  
Sung Woo Jee ◽  
Jung Sik Kim ◽  
Eun Ju Lee ◽  
Seong Ku Woo ◽  
Soo Jhi Suh




2017 ◽  
Vol 78 (2) ◽  
pp. 516-527 ◽  
Author(s):  
Kosuke Hiramatsu ◽  
Satoshi Serada ◽  
Takayuki Enomoto ◽  
Yusuke Takahashi ◽  
Satoshi Nakagawa ◽  
...  






2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Yong Xi ◽  
Xin Nie ◽  
Jing Wang ◽  
Lingling Gao ◽  
Bei Lin

Background. BMPER has been reported to be associated with the biological behavior of a few malignant tumors, but the mechanism is still unclear. We aimed to detect BMPER expression in ovarian epithelial tumor tissues and its effects on their biological behaviors, as well as to elucidate the possible mechanism. Methods. BMPER expression in ovarian epithelial tumor tissues was detected by immunohistochemistry. BMPER expression in ovarian cancer cell lines was inhibited via RNA interference. Changes in the malignant behaviors of ovarian cancer cells were detected by MTT, wound healing, Transwell, and flow cytometry assays. Changes in proteins in the MAPK and autophagy-related signaling pathways were detected by Western blot analysis. Results. The expression of BMPER was significantly upregulated in ovarian epithelial malignant tumors and was related to increased lymph node metastasis and lower survival rate. High BMPER expression is an independent risk factor for poor prognosis in patients. Inhibition of BMPER inhibited the proliferation, invasion, and migration of ovarian cancer cells and promoted apoptosis. In addition, BMPER downregulation decreased the expression of PCNA, Bcl-2, MMP2, and MMP9 and increased the expression of Bax. Moreover, the levels of p-ERK, p-MEK, and the autophagy-related protein p-mTOR were decreased, and Beclin 1 levels and the LC3II/I ratio were increased. Conclusions. Our findings indicated that BMPER is closely related to poor prognosis in ovarian cancer. BMPER plays a role in promoting the malignant biological behavior of tumor cells through the MAPK and autophagy-related signaling pathways.



2002 ◽  
Vol 13 (1) ◽  
pp. 3
Author(s):  
Il Soo Park ◽  
Tae Bon Koo ◽  
Dong Ja Kim ◽  
Tae In Park




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