scholarly journals TFIIH Basal Transcription Factor Complex Helicase XPD Subunit

2020 ◽  
Author(s):  
Keyword(s):  
Transcription Factor ◽  
Basal Transcription ◽  
Basal Transcription Factor ◽  
Transcription Factor Complex

scholarly journals Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH).

1994 ◽  
Vol 13 (7) ◽  
pp. 1645-1653 ◽  
Author(s):  
A.J. van Vuuren ◽  
W. Vermeulen ◽  
L. Ma ◽  
G. Weeda ◽  
E. Appeldoorn ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Xeroderma Pigmentosum ◽  
Basal Transcription ◽  
Basal Transcription Factor ◽  
Repair Defect

scholarly journals The requirement for the basal transcription factor IIE is determined by the helical stability of promoter DNA.

1995 ◽  
Vol 14 (4) ◽  
pp. 810-819 ◽  
Author(s):  
F.C. Holstege ◽  
D. Tantin ◽  
M. Carey ◽  
P.C. van der Vliet ◽  
H.T. Timmers
Keyword(s):  
Transcription Factor ◽  
Basal Transcription ◽  
Basal Transcription Factor ◽  
Promoter Dna

scholarly journals The MYND Motif Is Required for Repression of Basal Transcription from the Multidrug Resistance 1 Promoter by the t(8;21) Fusion Protein

1998 ◽  
Vol 18 (6) ◽  
pp. 3604-3611 ◽  
Author(s):  
Bart Lutterbach ◽  
Daxi Sun ◽  
John Schuetz ◽  
Scott W. Hiebert
Keyword(s):  
Transcription Factor ◽  
Multidrug Resistance ◽  
Acute Leukemia ◽  
Transcriptional Repression ◽  
Chromosomal Translocations ◽  
Heptad Repeat ◽  
Chemotherapeutic Drugs ◽  
Basal Transcription ◽  
Mdr 1 ◽  
Transcription Factor Complex

ABSTRACTChromosomal translocations in acute leukemia that affect the AML-1/CBFβ transcription factor complex create dominant inhibitory proteins. However, the mechanisms by which these proteins act remain obscure. Here we demonstrate that the multidrug resistance 1 (MDR-1) promoter is a target for AML/ETO transcriptional repression. This repression is of basal, not activated, expression from the MDR-1 promoter and thus represents a new mechanism for AML/ETO function. We have defined two domains in AML/ETO that are required for repression of basal transcription from the MDR-1 promoter: a hydrophobic heptad repeat (HHR) motif and a conserved zinc finger (ZnF) domain termed the MYND domain. The HHR mediates formation of AML/ETO homodimers and AML/ETO-ETO heterodimers. Single serine substitutions at conserved cysteine residues within the predicted ZnFs also abrogate transcriptional repression. Finally, we observe that AML/ETO can also inhibit Ets-1 activation of the MDR-1 promoter, indicating that AML/ETO can disrupt both basal and Ets-1-dependent transcription. The fortuitous inhibition of MDR-1 expression in t(8;21)-containing leukemias may contribute to the favorable response of these patients to chemotherapeutic drugs.

Evolution, structure and assembly of basal Transcription Factor II D

10.33540/207 ◽  
2020 ◽  
Author(s):  
◽  
Simona Vladimirova Antonova
Keyword(s):  
Transcription Factor ◽  
Basal Transcription ◽  
Basal Transcription Factor ◽  
Factor Ii
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