scholarly journals Recurrence Prediction Score of the Localy Advance Breast Cancer in West Sumatera Province, Indonesia

2021 ◽  
Vol 5 (4) ◽  
pp. 1166-1172
Author(s):  
Shinta Qorina ◽  
Wirsma Arif Harahap ◽  
Ricvan Dana Nindrea
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Lymphovascular Invasion ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Cancer Recurrence ◽  
Advanced Breast ◽  
Breast Cancer Recurrence ◽  
Prognosis Factors ◽  
Histopathological Type

Introduction: Breast cancer is the most common malignancy that occurs in women in the world, which is about 18% of cancer cases that occur in women. Every year there are 1 million new cases of breast cancer worldwide and nearly 60,000 patients die from this disease. Therefore, the authors want to find out more about the prognosis factors that play a role in influencing the survival of patients with locally advanced breast cancer in Padang city, West Sumatera Province Indonesia. Methods: This study is a retrospective case-control study of locally advanced breast cancer for patients in Padang city. The study was conducted at the Surgical Oncology Division of Dr. M Djamil Padang Hospital, Ropana Suri Hospital, Ibnu Sina Hospital and Siti Rahmah Padang Hospital from September 2018 to December 2018. The total number of samples for the two groups was 242 people. The sampling technique used was convenience sampling. Results: In this study 4 prognostic factors were found that had a significant effect on predicting breast cancer recurrence, namely histopathological type, stage, regional lymph and lymphovascular invasion with p <0.05. Conclusion: Prognosis factors that influence breast cancer recurrence are histopathological type, stage, regional lymph node status and lymphovascular invasion. A scoring system is obtained that is good enough to predict the possibility of breast cancer recurrence.

scholarly journals Recurrence Prediction Score of the Localy Advance Breast Cancer in West Sumatera Province, Indonesia

2021 ◽  
Vol 5 (9) ◽  
pp. 890-896
Author(s):  
Shinta Qorina ◽  
Wirsma Arif Harahap ◽  
Ricvan Dana Nindrea
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Lymphovascular Invasion ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Cancer Recurrence ◽  
Advanced Breast ◽  
Breast Cancer Recurrence ◽  
Prognosis Factors ◽  
Histopathological Type

Introduction: Breast cancer is the most common malignancy that occurs in women in the world, which is about 18% of cancer cases that occur in women. Every year there are 1 million new cases of breast cancer worldwide and nearly 60,000 patients die from this disease. Therefore, the authors want to find out more about the prognosis factors that play a role in influencing the survival of patients with locally advanced breast cancer in Padang city, West Sumatera Province Indonesia. Methods: This study is a retrospective case-control study of locally advanced breast cancer for patients in Padang city. The study was conducted at the Surgical Oncology Division of Dr. M Djamil Padang Hospital, Ropana Suri Hospital, Ibnu Sina Hospital and Siti Rahmah Padang Hospital from September 2018 to December 2018. The total number of samples for the two groups was 242 people. The sampling technique used was convenience sampling. Results: In this study 4 prognostic factors were found that had a significant effect on predicting breast cancer recurrence, namely histopathological type, stage, regional lymph and lymphovascular invasion with p <0.05. Conclusion: Prognosis factors that influence breast cancer recurrence are histopathological type, stage, regional lymph node status and lymphovascular invasion. A scoring system is obtained that is good enough to predict the possibility of breast cancer recurrence.

P206 Ipsilateral breast cancer recurrence in conservative treatment for locally advanced breast cancer

The Breast ◽  
2015 ◽  
Vol 24 ◽  
pp. S96
Author(s):  
G.F.A. Carrara ◽  
C.S. Neto ◽  
L.F. Abrão-Machado ◽  
J.S. Nunes ◽  
M.A.A.K. Folgueira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Conservative Treatment ◽  
Advanced Breast Cancer ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Cancer Recurrence ◽  
Advanced Breast ◽  
Breast Cancer Recurrence ◽  
Ipsilateral Breast

Overexpression of chemokine receptor CXCR4 in cancer specimens following neoadjuvant chemotherapy predicts outcome in patients with locally advanced breast cancer (LABC)

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 10578-10578 ◽  
Author(s):  
N. T. Holm ◽  
K. Byrnes ◽  
M. MacDonald ◽  
F. Abreo ◽  
F. Ampil ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Advanced Breast Cancer ◽  
Chemokine Receptor ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Cancer Recurrence ◽  
Advanced Breast ◽  
Western Blots ◽  
Number Of Patients

10578 Background: Despite significant advances made in the treatment of locally advanced breast cancer (LABC) with neoadjuvant chemotherapy, a significant number of patients continue to die. A molecular predictor to identify those who are at an increased risk for relapse is sorely needed. CXCR4 is a chemokine receptor that has been linked to breast cancer invasion and metastasis. We postulate that CXCR4 overexpression levels in cancer specimens following neoadjuvant chemotherapy predict cancer outcome in patients with LABC. Methods: 54 patients with LABC were prospectively accrued and analyzed. All had neoadjuvant chemotherapy, followed by definitive surgical and adjuvant chemo-radiation therapy. Study homogeneity was maintained by standardized treatment, surveillance, and compliance protocols. A 1 cm 3 cancer from the surgical specimens of each patient was retrieved for analysis. CXCR4 levels were detected using Western blots and results were quantified against 1 μg of HeLa cells (positive controls). CXCR4 expression was defined as low (<6.6 fold) or high (= 6.6 fold). Primary endpoints were cancer recurrence and death. Statistical analysis performed included Kaplan-Meier survival analysis, log-rank test, and Cox proportional hazard model. Results: With a median follow-up of 30 months, patients whose tumors had high CXCR4 overexpression (= 6.6 fold) had a statistically significantly higher incidence of recurrence (p= 0.0009) and cancer-related death (p= 0.0168) than those in the low CXCR4 group (< 6.6 fold). After adjusting for tumor size, nodal status, ER, PR and HER-2 status, the relative risk for recurrence and death in the high CXCR4 group was 27.3-fold (p=0.001; 95% CI: 6.2 to 120.8) and 4.8-fold (p=0.0076; 95% CI: 1.5 to 15.0) higher than those in the low CXCR4 group, respectively. Conclusion: High CXCR4 overexpression in cancer specimens following neoadjuvant chemotherapy was highly predictive of cancer recurrence and cancer death in patients with LABC. No significant financial relationships to disclose.

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