As business failure is a high probability event that influences the operation efficiency of the entrepreneurial ecosystem, it is necessary to know how to manage business failure experience to promote serial entrepreneurship and improve circulation in the ecosystem. While most scholars agree that it is different between failure and exit, DeTienne suggests that exit could be a way to avoid failure and protect the passion and financial condition of entrepreneurs. Therefore, this chapter analyzes the difference of failure and exit and conducts a model to help entrepreneurs decide whether to exit and how to choose a better way to exit entrepreneurship. In the meantime, this chapter analyzes why entrepreneurial exit can improve the operation efficiency of entrepreneurial ecosystem, and also it would give some ideas about how to bound from failure and benefit from failure to do better next time. After reading this chapter, entrepreneurs have the idea that failure is controllable and exit may be a restart to do business more successfully.