scholarly journals Necrolytic Acral Erythema

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Histopathological Examination ◽  
Inflammatory Cells ◽  
Hepatitis C Virus Infection ◽  
Hepatitis C Infection ◽  
Acral Erythema ◽  
Necrolytic Migratory Erythema ◽  
Necrolytic Acral Erythema

Background: Necrolytic acral erythema (NAE) is a rare dermatosis which has been regarded as an early cutaneous marker of hepatitis C virus infection. The clinical manifestasion of NAE is similar to necrolytic migratory erythema, psoriasis and tinea corporis. The difference is that the patients with NAE also suffer from hepatitis C virus infection. Case: A 59 year old woman came and complained about itchy erythematous-violaceous plaques since a year ago. The patient has a history of hepatitis C infection since 2 years ago. On the superior and inferior extremities region, there were erythematous-violaceous plaques witch is partially hyperpigmentation with well-demarcated border, multiple discretes with thin scales and lichenification. Histopathological examination of the lesion obtained psoriasiform, hyperkeratosis, neutophylic microabscess, epidermal necrosis, spongiosis and infiltration of inflammatory cells in the epidermis. Discussion: Necrolytic acral erythema has been reported exclusively in patients with hepatitis C and is thought to be pathognomonic of this infection. Acute lesions often show erythema with vesicles and flaccid bullae. Chronic lesions appear as erythematous to violaceous plaques with thick scales, erosions and crust. Acral sites are predominantly involved. The histopathological examination shows psoriasiform hyperplasia epidermal, neutrophylic microabscesses, dilatation of small vessels, parakeratosis and infiltration of inflammatory cells. In this case, the physical and histopathological examination support the diagnosis of NAE.

Necrolytic acral erythema: A cutaneous sign of hepatitis C virus infection

2005 ◽  
Vol 53 (2) ◽  
pp. 247-251 ◽  
Author(s):  
Mahmoud A. Abdallah ◽  
Mohamed Y. Ghozzi ◽  
Hoda A. Monib ◽  
Aisha M. Hafez ◽  
Kim M. Hiatt ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatitis C Virus Infection ◽  
Acral Erythema ◽  
Necrolytic Acral Erythema

scholarly journals Low prevalence of necrolytic acral erythema in patients with chronic hepatitis C virus infection

2012 ◽  
Vol 67 (5) ◽  
pp. 962-968 ◽  
Author(s):  
Brian A. Raphael ◽  
Zachariah L. Dorey-Stein ◽  
Jason Lott ◽  
Valerianna Amorosa ◽  
Vincent Lo Re ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Hepatitis C Virus Infection ◽  
Acral Erythema ◽  
Chronic Hepatitis C Virus ◽  
Necrolytic Acral Erythema ◽  
Low Prevalence

Necrolytic acral erythema in Egyptian patients with hepatitis C virus infection

2006 ◽  
Vol 21 (7) ◽  
pp. 1200-1206 ◽  
Author(s):  
Tarek M El-Ghandour ◽  
Mohammad A Sakr ◽  
Hatem El-Sebai ◽  
Tarek F El-Gammal ◽  
Manal H El-Sayed
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatitis C Virus Infection ◽  
Acral Erythema ◽  
Egyptian Patients ◽  
Necrolytic Acral Erythema

scholarly journals Necrolytic acral erythema: a rare skin disease associated with hepatitis C virus infection

2016 ◽  
Vol 91 (5) ◽  
pp. 649-651 ◽  
Author(s):  
Luciane Francisca Fernandes Botelho ◽  
Milvia Maria Simões e Silva Enokihara ◽  
Mauro Yoshiaki Enokihara
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Skin Disease ◽  
Hepatitis C Virus Infection ◽  
Acral Erythema ◽  
Necrolytic Acral Erythema

Incidence of Invasive Pneumococcal Disease Higher Among People Notified With Markers of Hepatitis C Virus Infection: Population-based Surveillance in Victoria, Australia, 2001–2017

2020 ◽  
Author(s):  
Katherine B Gibney ◽  
Jennifer MacLachlan ◽  
Rachel Coutts ◽  
Nasra Higgins ◽  
Janet Strachan
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
General Population ◽  
Virus Infection ◽  
Invasive Pneumococcal Disease ◽  
Pneumococcal Disease ◽  
Pneumococcal Vaccination ◽  
Hepatitis C Virus Infection ◽  
Hepatitis C Infection ◽  
Vaccine Serotypes

Abstract Background Worse outcomes from invasive pneumococcal disease (IPD) have been reported among those coinfected with hepatitis C. We aimed to establish if IPD notification rates are higher among people notified with markers of hepatitis C virus infection than the general population. Methods IPD cases notified in Victoria, Australia, from July 2001–December 2017 were linked with hepatitis C cases (diagnosed by serology or PCR testing) notified from January 1991–December 2017. IPD incidence was calculated using population data and the estimated number of Victorians with hepatitis C. Results From July 2001–December 2017, 6407 IPD cases were notified. Hepatitis C infection was notified in 342 (5.3%) of IPD cases overall, and 24.4% among IPD cases aged 45–49 years. Among IPD cases also notified with hepatitis C, 55.3% were infected with 13-valent pneumococcal conjugate vaccine serotypes and 82.8% with 23-valent pneumococcal polysaccharide vaccine serotypes. Compared with IPD cases without hepatitis C, IPD cases also notified with hepatitis C were younger (mean age, 45.7 vs 49.4 years; P = .011) and more often male (65.5% vs 55.5%, P < .001). Annual IPD notification incidence was 6.8/100 000 among people without hepatitis C and 39.4/100 000 among people with hepatitis C (IRR, 5.8; 95% CI, 5.2–6.4; P < .001). Conclusions IPD notification incidence was 5 times higher among people notified with markers of hepatitis C than the general population. Pneumococcal vaccination should be offered to people with markers of hepatitis C virus infection. To facilitate appropriate treatment, young and middle-aged adults with IPD should be tested for hepatitis C.

scholarly journals Morphologic Features of Extrahepatic Manifestations of Hepatitis C Virus Infection

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Huaibin M. Ko ◽  
Juan C. Hernandez-Prera ◽  
Hongfa Zhu ◽  
Steven H. Dikman ◽  
Harleen K. Sidhu ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Immune Complex ◽  
Porphyria Cutanea Tarda ◽  
Membranous Glomerulonephritis ◽  
Hepatitis C Virus Infection ◽  
Extrahepatic Manifestations ◽  
Hepatitis C Infection ◽  
Small Vessels

Cirrhosis and hepatocellular carcinoma are the prototypic complications of chronic hepatitis C virus infection in the liver. However, hepatitis C virus also affects a variety of other organs that may lead to significant morbidity and mortality. Extrahepatic manifestations of hepatitis C infection include a multitude of disease processes affecting the small vessels, skin, kidneys, salivary gland, eyes, thyroid, and immunologic system. The majority of these conditions are thought to be immune mediated. The most documented of these entities is mixed cryoglobulinemia. Morphologically, immune complex depositions can be identified in small vessels and glomerular capillary walls, leading to leukoclastic vasculitis in the skin and membranoproliferative glomerulonephritis in the kidney. Other HCV-associated entities include porphyria cutanea tarda, lichen planus, necrolytic acral erythema, membranous glomerulonephritis, diabetic nephropathy, B-cell non-Hodgkin lymphomas, insulin resistance, sialadenitis, sicca syndrome, and autoimmune thyroiditis. This paper highlights the histomorphologic features of these processes, which are typically characterized by chronic inflammation, immune complex deposition, and immunoproliferative disease in the affected organ.

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