scholarly journals Effect of Subcutaneous Adrenaline/Saline/Lidocaine Injection on Split-Thickness Skin Graft Donor Site Wound Healing

2021 ◽  
Vol 64 (1) ◽  
pp. 107-112
Author(s):  
Kohei Fukuoka ◽  
Shunjiro Yagi ◽  
Yoshiko Suyama ◽  
Wataru Kaida ◽  
Maki Morita ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Graft ◽  
Donor Site ◽  
Split Thickness Skin Graft ◽  
Thickness Skin ◽  
Lidocaine Injection ◽  
Graft Donor

scholarly journals CICAFAST: comparison of a biological dressing composed of fetal fibroblasts and keratinocytes on a split-thickness skin graft donor site versus a traditional dressing: a randomized controlled trial

Trials ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Alexandra Poinas ◽  
Pierre Perrot ◽  
Judith Lorant ◽  
Olivier Nerrière ◽  
Jean-Michel Nguyen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Skin Graft ◽  
Donor Site ◽  
Split Thickness Skin Graft ◽  
Skin Grafts ◽  
Thickness Skin ◽  
Fetal Fibroblasts ◽  
Biological Dressing ◽  
Graft Donor

Abstract Background Wound repair is one of the most complex biological processes of human life. Allogeneic cell-based engineered skin substitutes provide off-the-shelf temporary wound coverage and act as biologically active dressings, releasing growth factors, cytokines and extracellular matrix components essential for proper wound healing. However, they are susceptible to immune rejection and this is their major weakness. Thanks to their low immunogenicity and high effectiveness in regeneration, fetal skin cells represent an attractive alternative to the commonly used autologous and allogeneic skin grafts. Methods/design We developed a new dressing comprising a collagen matrix seeded with a specific ratio of active fetal fibroblasts and keratinocytes. These produce a variety of healing growth factors and cytokines which will increase the speed of wound healing and induce an immunotolerant state, with a slight inflammatory reaction and a reduction in pain. The objective of this study is to demonstrate that the use of this biological dressing for wound healing at the split-thickness skin graft (STSG) donor site, reduces the time to healing, decreases other co-morbidities, such as pain, and improves the appearance of the scar. This investigation will be conducted as part of a randomized study comparing our new biological dressing with a conventional treatment in a single patient, thus avoiding the factors that may influence the healing of a graft donor site. Discussion This clinical trial should enable the development of a new strategy for STSG donor-wound healing based on a regenerative dressing. The pain experienced in the first few days of STSG healing is well known due to the exposure of sensory nerve endings. Reducing this pain will also reduce analgesic drug intake and the duration of sick leave. Our biological dressing will meet the essential need of surgeons to “re-crop” from existing donor sites, e.g., for thermal-burn patients. By accelerating healing, improving the appearance of the scar and reducing pain, we hope to improve the conditions of treatment for skin grafts. Trial registration ClinicalTrials.gov, ID: NCT03334656. Registered on 7 November 2017.

scholarly journals Application of Honey and Transparent Dressing to Split Thickness Skin Graft Donor Site and Its Effect on Epithelialization Rate

1970 ◽  
Vol 1 (3) ◽  
Author(s):  
Teuku A. ◽  
Nandita Melati P. ◽  
Gentur Sudjatmiko ◽  
Asrofi S. ◽  
Ishandono D.
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Skin Graft ◽  
Donor Site ◽  
Split Thickness Skin Graft ◽  
Parallel Design ◽  
Thickness Skin ◽  
Graft Donor ◽  
The Mean ◽  
Clinical Photograph

Background: Split thickness skin graft (STSG) is one of the modalities used to close a defect. The donor site can be healed secondarily with tulle grass and moist gauze after 14 days and with transparent dressing will take about 10-13 days. Recently the wound healing by using honey application has been used. Whether or not using honey application with transparent dressing will hasten the epithelialization rate of the STSG donor site is now in question. Method: This research is an open, non-randomized clinical trial with a parallel design and intervention using honey application with transparent dressing. A total of 19 patients (7 female and 8 male) were included in this study. The reapplication of honey was done every two days. The patients was followed up every day, with clinical photograph taken and complaints such as pain, odor and infection noted. Results: The mean epithelialization rate of the donor site treated with honey and transparent dressing was 9,74 (+0,24) days compared to 10,79 (+1,23) days in the transparent-dressing-only group (p=0,00). Conclusion: The application of honey with transparent dressing to cover for STSG donor site led to a faster epithelialization rate, less odor and less pain. Commercial honey was used, and readily available.

scholarly journals Split-thickness skin graft donor-site morbidity: A systematic literature review

Burns ◽  
2021 ◽  
Author(s):  
Malachy Asuku ◽  
Tzy-Chyi Yu ◽  
Qi Yan ◽  
Elaine Böing ◽  
Helen Hahn ◽  
...  
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Skin Graft ◽  
Donor Site ◽  
Donor Site Morbidity ◽  
Split Thickness Skin Graft ◽  
Thickness Skin ◽  
Graft Donor

Use of Honey as an Adjunct in the Healing of Split-Thickness Skin Graft Donor Site

2003 ◽  
Vol 29 (2) ◽  
pp. 168-172
Author(s):  
AYKUT MISIRLIOGLU ◽  
SINEM EROGLU ◽  
NACI KARACAOGLAN ◽  
MITHAT AKAN ◽  
TAYFUN AKOZ ◽  
...  
Keyword(s):  
Skin Graft ◽  
Donor Site ◽  
Split Thickness Skin Graft ◽  
Thickness Skin ◽  
Graft Donor

scholarly journals Immediate Regrafting of the Split Thickness Skin Graft Donor Site Assists Healing

2017 ◽  
Vol 5 (5) ◽  
pp. e1339 ◽  
Author(s):  
Brian P. Bradow ◽  
Geoffrey G. Hallock ◽  
Samuel P. Wilcock
Keyword(s):  
Skin Graft ◽  
Donor Site ◽  
Split Thickness Skin Graft ◽  
Thickness Skin ◽  
Graft Donor

Effect of Subcutaneous Epinephrine/Saline/Local Anesthetic Versus Saline-Only Injection on Split-Thickness Skin Graft Donor Site Perfusion, Healing, and Pain

2013 ◽  
Vol 34 (2) ◽  
pp. e80-e86 ◽  
Author(s):  
Sigrid Blome-Eberwein ◽  
Michael Abboud ◽  
Daniel D. Lozano ◽  
Rohit Sharma ◽  
Sherrine Eid ◽  
...  
Keyword(s):  
Skin Graft ◽  
Local Anesthetic ◽  
Donor Site ◽  
Split Thickness Skin Graft ◽  
Thickness Skin ◽  
Graft Donor

Use of lyophilized bovine collagen for split-thickness skin graft donor site management

Burns ◽  
2008 ◽  
Vol 34 (7) ◽  
pp. 1011-1014 ◽  
Author(s):  
Fatih Uygur ◽  
Rahmi Evınc ◽  
Ersin Ulkur ◽  
Bahattin Celıkoz
Keyword(s):  
Skin Graft ◽  
Donor Site ◽  
Split Thickness Skin Graft ◽  
Site Management ◽  
Bovine Collagen ◽  
Thickness Skin ◽  
Graft Donor

CARE OF THE SPLIT-THICKNESS SKIN GRAFT DONOR SITE

1974 ◽  
Vol 14 (2) ◽  
pp. 163-167 ◽  
Author(s):  
GARY D. FRIEDMAN ◽  
ANGELO CAPOZZI ◽  
VINCENT R. PENNISI
Keyword(s):  
Skin Graft ◽  
Donor Site ◽  
Split Thickness Skin Graft ◽  
Thickness Skin ◽  
Graft Donor
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