Proteomic Profiling of Human Umbilical Cord Blood Serum and its Potential Use in Regenerative Therapies

A few biomedical applications of Human umbilical cord blood serum used for the treatment of blood disorders and ocular therapy have been documented. Umbilical cords are relatively free of bacterial and viral contamination and often discarded after birth. Previous studies on human umbilical cord blood serum have certain factors exhibiting a distinctive differentiation potential and pharmacological influence like to boost anti-inflammatory, analgesic, and wound healing property. Cord blood can be collected without pain and cryopreserved without causing any changes in the functional properties. Human umbilical cord blood serum has been increasingly used in regenerative medicine because of their ability to treat tissue injury and causing immunomodulatory properties. Human cord blood serum possesses a striking natural resemblance of nutrients required for cell/tissue engineering. Cord blood serum being allogenic in nature, makes it a favorable biomaterial over other autogenous therapies. It contains a number of proteins that are exchanged from the mother to the fetus for growth and development.These exclusive proteins may perhaps participate in the modulation of cell proliferation and differentiation along with accelerated migration of keratinocyte at the wound edge with the generation of the intact epithelium.In the present study, umbilical cord blood serum was obtained from 35 patients and was subjected toMass Spectrometry. A total of 99 proteins were identified in the sample. Functions of proteins were analyzed using the Uniprot database.Thus, understanding the protein functions could give us insight into the regenerative properties of umbilical cord blood serum.