Efficacy of Optical Coherence Tomography Angiography in Measuring the Foveal Avascular Zone Area in Patients with Branch Retinal Vein Occlusion

Purpose: To determine the relationship between morphological parameters of the foveal avascular zone (FAZ) in the optical coherence tomography angiographic (OCTA) images and the best-corrected visual acuity (BCVA) in branch retinal vein occlusion (BRVO). Methods: This was a retrospective cross-sectional study. Eyes with BRVO without apparent macular edema were studied. The superficial FAZ in 3 × 3 mm OCTA images were delineated manually. The size and shape, the circularity and axial ratio, of the FAZ were determined, and the values were compared to that of the controls. The correlation of these parameters with the BCVA was analyzed. Results: The mean FAZ area was larger in BRVO eyes than in controls, but the larger size was not correlated with the BCVA (BRVO, 0.49 ± 0.12 mm2; control, 0.38 ± 0.12 mm2; P = .135). The axial ratio of the BRVO eyes was significantly larger than that of controls ( P < .001). The axial ratio was significantly correlated with BCVA ( R = .382, P = .050). Although the circularity was significantly smaller in the BRVO eyes than that in controls ( P < .001), it was not significantly correlated with the BCVA. Conclusion: The shape of the FAZ would be a more appropriate parameter than the size in determining BCVA in eyes with BRVO.

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Comparison of foveal avascular zone between optical coherence tomography angiography and fluorescein angiography in patients with retinal vein occlusion

PLoS ONE ◽

10.1371/journal.pone.0217849 ◽

2019 ◽

Vol 14 (6) ◽

pp. e0217849 ◽

Cited By ~ 2

Author(s):

Jens Ulrich Werner ◽

Felix Böhm ◽

Gabriele E. Lang ◽

Jens Dreyhaupt ◽

Gerhard K. Lang ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Fluorescein Angiography ◽

Retinal Vein Occlusion ◽

Optical Coherence Tomography Angiography ◽

Foveal Avascular Zone ◽

Optical Coherence ◽

Vein Occlusion ◽

Avascular Zone

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Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)

10.21203/rs.2.15193/v1 ◽

2019 ◽

Author(s):

Lulu Chen ◽

Mingzhen Yuan ◽

Lu Sun ◽

Yuelin Wang ◽

Youxin Chen

Keyword(s):

Optical Coherence Tomography ◽

Retinal Vein Occlusion ◽

Branch Retinal Vein Occlusion ◽

Optical Coherence Tomography Angiography ◽

Foveal Avascular Zone ◽

Microvascular Network ◽

Vein Occlusion ◽

Avascular Zone ◽

Radial Peripapillary Capillary ◽

Fellow Eyes

Abstract Purpose: To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients. Methods: Forty-seven unilateral BRVO patients were enrolled. A 3*3 mm scan centered on fovea followed by a 4.5*4.5 mm scan centered on optic nerve head (ONH) were obtained in BRVO eyes and fellow eyes of each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) in superficial (SVC) and deep vascular complex (DVC) of macula and radial peripapillary capillary (RPC) were automatically calculated. Parameters of FAZ region including size, perimeter, acircularity index (AI) and foveal density 300 (FD-300) were measured. Results: VDs of SCV and DVC were significantly lower, especially in affected regions, in BRVO eyes compared with fellow eyes ( P <0.05). BRVO affected eyes has larger FAZ size, FAZ perimeter, AI and lower FD-300 compared with fellow eyes (all P <0.05). The average vessel density in whole area and peripapillary area in BRVO eyes were significantly lower compared with fellow eyes ( P <0.05). Conclusions: OCTA provided quantitative information of vascular changes in BRVO. FAZ in BRVO eyes showed significant morphological alterations and decreases of VD in surrounding area. Decreases of VD existed not only in SVC and DVC in macular region but also in RPCs in BRVO eyes. Key words: optical coherence tomography angiography, retinal vasculature, foveal avascular zone, radial peripapillary capillary, branch retinal vein occlusion

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Optical Coherence Tomography Angiography of the Foveal Avascular Zone in Retinal Vein Occlusion

Ophthalmologica ◽

10.1159/000445482 ◽

2016 ◽

Vol 235 (4) ◽

pp. 195-202 ◽

Cited By ~ 29

Author(s):

Juliana Wons ◽

Maximilian Pfau ◽

Magdalena A. Wirth ◽

Florentina J. Freiberg ◽

Matthias D. Becker ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Retinal Vein Occlusion ◽

Optical Coherence Tomography Angiography ◽

Plexiform Layer ◽

Foveal Avascular Zone ◽

Inner Plexiform Layer ◽

Optical Coherence ◽

Vein Occlusion ◽

Avascular Zone ◽

Fellow Eyes

Purpose: The aim of the study was to visualize and to quantify pathological foveal avascular zone (FAZ) alterations through optical coherence tomography angiography (OCT-A) in eyes with retinal vein occlusion (RVO) in comparison to the unaffected fellow eyes. Procedures: OCT-A was conducted with the Avanti® RTVue 100 XR system (Optovue Inc., Fremont, Calif., USA). The borders of the superficial vascular layer (SVL) were defined as 3 μm below the internal limiting membrane and 15 μm below the inner plexiform layer, and for the deep vascular layer (DVL) as 15 and 70 μm below the inner plexiform layer, respectively. The length of the horizontal, vertical and maximum FAZ was manually measured for the SVL and DVL in each eye. Additionally, the angle between the maximum FAZ diameter and the papillomacular plane was measured. Results: OCT-A depicted defects within the perifoveal vasculature in eyes with branch retinal vein occlusion (BRVO; n = 11) and central retinal vein occlusion (CRVO; n = 8). These resulted in an enlargement of the maximum FAZ diameter in eyes with RVO (n = 19) in comparison to the healthy fellow eyes (n = 19; 921 ± 213 vs. 724 ± 145 µm; p = 0.008). Furthermore, a significant correlation was found between best-corrected visual acuity (BCVA) and the maximum FAZ diameter in the DVL (Spearman's ρ = -0.423, p < 0.01). Lastly, in the eyes with RVO, the angle between the papillomacular plane and the maximum FAZ diameter was only in 21.05% (SVL) and 15.79% (DVL) of the cases at 0 ± 15 or 90 ± 15°, respectively. In healthy eyes, these angles (which putatively represent a regular FAZ configuration) were more prevalent (SVL 68.42 vs. 21.05%, p = 0.003; DVL 73.68 vs. 15.79%, p < 0.001). Conclusion: OCT-A shows morphological alterations of the FAZ in eyes with CRVO and BRVO. The correlation of the maximum FAZ diameter with BCVA suggests that these alterations are functionally relevant.

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Fundus Fluorescein Angiography, Optical Coherence Tomography, and Optical Coherence Tomography Angiography Findings in Branch Retinal Vein Occlusion

Güncel Retina Dergisi (Current Retina Journal) ◽

10.37783/crj-0144 ◽

2019 ◽

pp. 83-87

Keyword(s):

Optical Coherence Tomography ◽

Fluorescein Angiography ◽

Retinal Vein Occlusion ◽

Branch Retinal Vein Occlusion ◽

Optical Coherence Tomography Angiography ◽

Serous Retinal Detachment ◽

Optical Coherence ◽

Fundus Fluorescein Angiography ◽

Vein Occlusion ◽

Capillary Plexus

Even though the diagnosis depends on clinical examination, in cases with branch retinal vein occlusion (BRVO), fundus fluorescein angiography (FFA), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) provide unique data for follow-up, management and prognosis. In FFA, delay of laminar flow phase in the involved branch, hyperfluorescence due to leakage from the vessel wall in the late phases, hypofluorescence due to the blockage by hemorrhage, and soft exudates, and hyperfluorescence due to macular edema can be detected. In OCT, macular thickening, cystic spaces, serous retinal detachment, hyperreflective dots, disorganization of the outer retinal layers – particularly the photoreceptor inner and outer segments line and the external limiting membrane – can be seen. OCTA reveals non-perfusion, particularly in the deep capillary plexus.

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