scholarly journals Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines

Author(s):  
Hideki Hayashi ◽  
Yoshinao Kubo ◽  
Mai Izumida ◽  
Etsuhisa Takahashi ◽  
Hiroshi Kido ◽  
...  
2013 ◽  
Vol 198 (2) ◽  
pp. 487-493 ◽  
Author(s):  
Yoshikazu Fujimoto ◽  
Kinuyo Ozaki ◽  
Masahiro Maeda ◽  
Ken-ichi Nishijima ◽  
Hiroki Takakuwa ◽  
...  

2012 ◽  
Vol 68 (3) ◽  
pp. 226-232 ◽  
Author(s):  
Shihoko Komine-Aizawa ◽  
Ai Suzaki ◽  
Quang D. Trinh ◽  
Yasuyuki Izumi ◽  
Toshikatsu Shibata ◽  
...  

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Georgetta Cannon ◽  
Jenny Q. Gronemus ◽  
Margaret S. Williams ◽  
Michelle A. Callahan ◽  
R. Joel Lowy

Cell Reports ◽  
2021 ◽  
Vol 35 (7) ◽  
pp. 109159
Author(s):  
Xiaoyuan Bai ◽  
Wenxian Yang ◽  
Xiaohan Luan ◽  
Huizi Li ◽  
Heqiao Li ◽  
...  

2007 ◽  
Vol 88 (10) ◽  
pp. 2627-2635 ◽  
Author(s):  
Alexey A. Matskevich ◽  
Karin Moelling

In mammals the interferon (IFN) system is a central innate antiviral defence mechanism, while the involvement of RNA interference (RNAi) in antiviral response against RNA viruses is uncertain. Here, we tested whether RNAi is involved in the antiviral response in mammalian cells. To investigate the role of RNAi in influenza A virus-infected cells in the absence of IFN, we used Vero cells that lack IFN-α and IFN-β genes. Our results demonstrate that knockdown of a key RNAi component, Dicer, led to a modest increase of virus production and accelerated apoptosis of influenza A virus-infected cells. These effects were much weaker in the presence of IFN. The results also show that in both Vero cells and the IFN-producing alveolar epithelial A549 cell line influenza A virus targets Dicer at mRNA and protein levels. Thus, RNAi is involved in antiviral response, and Dicer is important for protection against influenza A virus infection.


2012 ◽  
Vol 206 (4) ◽  
pp. 495-503 ◽  
Author(s):  
Jie Zhou ◽  
Kelvin Kai-Wang To ◽  
Hui Dong ◽  
Zhong-Shan Cheng ◽  
Candy Choi-Yi Lau ◽  
...  

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