scholarly journals Roles of taurine-mediated tonic GABAA receptor activation in the radial migration of neurons in the fetal mouse cerebral cortex

2014 ◽  
Vol 8 ◽  
Author(s):  
Tomonori Furukawa ◽  
Junko Yamada ◽  
Tenpei Akita ◽  
Yoshitaka Matsushima ◽  
Yuchio Yanagawa ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Gabaa Receptor ◽  
Receptor Activation ◽  
Radial Migration ◽  
Fetal Mouse ◽  
Mouse Cerebral Cortex

scholarly journals AN ELECTRON MICROSCOPIC STUDY OF THE DEVELOPMENT OF SYNAPSES IN CULTURED FETAL MOUSE CEREBRUM CONTINUOUSLY EXPOSED TO XYLOCAINE

1971 ◽  
Vol 49 (2) ◽  
pp. 362-371 ◽  
Author(s):  
Pat G. Model ◽  
Murray B. Bornstein ◽  
Stanley M. Crain ◽  
George D. Pappas
Keyword(s):  
Cerebral Cortex ◽  
Fine Structure ◽  
Electron Microscope ◽  
Impulse Activity ◽  
Morphological Differentiation ◽  
Bioelectric Activity ◽  
Electron Microscopic ◽  
Fetal Mouse ◽  
Electrical Impulse ◽  
Mouse Cerebral Cortex

Explants of fetal mouse cerebral cortex, continuously exposed to the local anesthetic Xylocaine from the time of explantation to the time of fixation, were examined in the electron microscope to determine whether morphologically normal synapses and potentially functional interneuronal synaptic networks can form in the absence of electrical impulse activity. Morphological differentiation of complex synaptic networks proceeds normally, and the drug does not alter the fine structure of the formed synapses. These observations are consonant with the electrophysiological data which show that the potential for complex bioelectric activity can develop in the absence of its expression. The development and maturation of functional synaptic networks, then, is not contingent upon prior electrical impulse activity. These data support the concept that organized neuronal assemblies are formed in forward reference to their ultimate function.

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